# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2438711 | F | Antioxidant activity assessed as reduction of microsomal lipid per-oxidation level by measuring formation of malondialdehyde at 200 ug/ml after 90 mins by spectrophotometric analysis relative to control | 17 | ALA2434829 | assay format | Scientific Literature | ||
2. | ALA2438712 | F | Antioxidant activity assessed as decrease in hydroxyl radicals level by measuring formation of malondialdehyde at 200 ug/ml after 90 mins by spectrophotometric analysis relative to control | 17 | ALA2434829 | assay format | Scientific Literature | ||
3. | ALA2438713 | F | Antioxidant activity assessed as decrease in superoxide anions level by measuring formation of formazone at 200 ug/ml after 30 mins by spectrophotometric analysis relative to control | 17 | ALA2434829 | assay format | Scientific Literature | ||
4. | ALA2438841 | F | Antidyslipidemic activity in Charles foster rat assessed as increase in triton WR-1339-reduced post heparin lipolytic activity level in plasma at 100 mg/kg, po after 18 hrs by spectrophotometric analysis relative to triton-treated rat | Rattus norvegicus | 18 | ALA2434829 | organism-based format | Scientific Literature | |
5. | ALA2438842 | F | Antidyslipidemic activity in Charles foster rat assessed as decrease in triton WR-1339-induced triglyceride level in plasma at 100 mg/kg, po after 18 hrs relative to triton-treated rat | Rattus norvegicus | 18 | ALA2434829 | organism-based format | Scientific Literature | |
6. | ALA2438843 | F | Antidyslipidemic activity in Charles foster rat assessed as decrease in triton WR-1339-induced phospholipid level in plasma at 100 mg/kg, po after 18 hrs relative to triton-treated rat | Rattus norvegicus | 18 | ALA2434829 | organism-based format | Scientific Literature | |
7. | ALA2438845 | F | Antidyslipidemic activity in Charles foster rat assessed as decrease in triton WR-1339-induced total cholesterol level in plasma at 100 mg/kg, po after 18 hrs relative to triton-treated rat | Rattus norvegicus | 18 | ALA2434829 | organism-based format | Scientific Literature | |
8. | ALA3428784 | B | Binding affinity to 6His-tagged recombinant human NF-kappaB p50 N-terminal domain expressed in Escherichia coli BL21 (DE3) up to 10:1 compound to protein molar ratio after 2 hrs by mass spectrometric analysis | Homo sapiens | 5 | ALA3425410 | assay format | Scientific Literature | |
9. | ALA3428788 | B | Inhibition of TNF-alpha-stimulated NF-kappaB p50 (unknown origin) expressed in HEK293 cells at 1 to 100 uM preincubated for 4 hrs followed by TNF-alpha challenge measured after 24 hrs by secreted alkaline phosphatase reporter assay | Homo sapiens | 4 | ALA3425410 | cell-based format | Scientific Literature | |
10. | ALA3428789 | A | Cytotoxicity against human Jurkat T cells assessed as appearance of early apoptotic cells at 25 uM after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis | Homo sapiens | 6 | ALA3425410 | cell-based format | Scientific Literature | |
11. | ALA3428790 | A | Cytotoxicity against human Jurkat T cells assessed as appearance of late apoptotic cells at 25 uM after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis | Homo sapiens | 6 | ALA3425410 | cell-based format | Scientific Literature | |
12. | ALA3428791 | A | Cytotoxicity against human Jurkat T cells assessed as appearance of necrotic cells at 25 uM after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis | Homo sapiens | 6 | ALA3425410 | cell-based format | Scientific Literature | |
13. | ALA3428792 | A | Cytotoxicity against human Jurkat T cells assessed as appearance of viable cells at 25 uM after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis | Homo sapiens | 6 | ALA3425410 | cell-based format | Scientific Literature | |
14. | ALA4275233 | F | Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay | Mus musculus | 20 | ALA4270620 | cell-based format | Scientific Literature | |
15. | ALA4341749 | F | Antiinflammatory activity in mouse BV2 cells assessed as reduction in LPS-induced NO production at 20 uM incubated for 24 hrs by Griess method | Mus musculus | 13 | ALA4340541 | cell-based format | Scientific Literature | |
16. | ALA4341750 | P | Lipophilicity, log P of the compound | 12 | ALA4340541 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA4341757 | F | Neuroprotective activity against H2O2-induced toxicity in rat PC12 cells assessed as increase in cell viability at 20 uM pretreated for 24 hrs followed by H2O2 challenge and measured after 24 hrs by MTT assay | Rattus norvegicus | 12 | ALA4340541 | cell-based format | Scientific Literature | |
18. | ALA4341759 | F | Neuroprotective activity against 6-OHDA -induced toxicity in rat PC12 cells assessed as increase in cell viability at 20 uM pretreated for 24 hrs followed by 6-OHDA challenge and measured after 24 hrs by MTT assay | Rattus norvegicus | 12 | ALA4340541 | cell-based format | Scientific Literature | |
19. | ALA4341760 | F | Induction of neurite outgrowth in NGF-induced rat PC12 cells assessed as neurite bearing cells at 20 uM cotreated with 20 ng/ml NGF incubated for 48 hrs by light microscopy | Rattus norvegicus | 11 | ALA4340541 | cell-based format | Scientific Literature | |
20. | ALA4341763 | A | Cytotoxicity in mouse BV2 cells assessed as reduction in cell viability | Mus musculus | 12 | ALA4340541 | cell-based format | Scientific Literature |