| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2439451 | F | Induction of sensitization of human SW620 cells to conatumumab-induced apoptosis assessed as cell viability at 2.5 uM after 5 days by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA2439453 | A | Drug uptake in tumor of nude mouse xenografted with human LOX cells at 200 mg/kg, po measured at 8 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2439455 | A | Plasma concentration in nude mouse xenografted with human LOX cells at 200 mg/kg, po measured at 8 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2439457 | F | In vivo inhibition of XIAP BIR2 domain in human LOX cells xenografted in nude mouse assessed as potentiation of conatumumab-induced caspase 3/7 activity at 200 mg/kg, po after 8 hrs by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2439459 | F | In vivo inhibition of XIAP BIR2 domain in human LOX cells xenografted in nude mouse assessed as increase in caspase 3/7 activity at 200 mg/kg, po after 8 hrs by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA2439460 | B | Inhibition of cIAP1/2 in human MDA-MB-231 cells assessed as induction of TNFalpha level at 0.37 to 3.3 uM after 19 hrs by ELISA | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA2439462 | F | Potentiation of conatumumab-induced apoptosis in human Capan1 cells at 2.5 uM after 5 days by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA2439463 | F | Potentiation of conatumumab-induced apoptosis in human SKMES1 cells at 2.5 uM after 5 days by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA2439464 | F | Potentiation of conatumumab-induced apoptosis in human U118MG cells at 2.5 uM after 5 days by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA2439465 | F | Induction of sensitization of human AGS cells to conatumumab-induced apoptosis assessed as cell viability at 2.5 uM after 5 days by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA2439466 | F | Induction of sensitization of human PC3 cells to conatumumab-induced apoptosis assessed as cell viability at 2.5 uM after 5 days by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA2439467 | F | Induction of sensitization of human SW620 cells to conatumumab-induced apoptosis assessed as cell viability after 5 days by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA2439927 | F | Induction of apoptosis in human SW620 cells assessed as cell viability at 0.37 to 10 uM after 5 days by MTS assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA2439928 | B | Inhibition of GST-tagged full length XIAP BIR2 domain-mediated caspase 3/7 cleavage in human HeLa S3 cell lysates assessed as cleavage of Ac-DEVD-AFC after 4 hrs in presence of cytochrome C and dATP | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA2439929 | B | Selectivity ratio of IC50 for 6xhistidine-thrombin-TEV-tagged cIAP1 BIR2 domain (174 to 256) (unknown origin) to IC50 for 6xhistidine-thrombin-TEV-tagged XIAP BIR2 domain (124 to 240) (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA2439930 | B | Displacement of AVPIAQKSEK (epsilon-biotin)-OH from 6xhistidine-thrombin-TEV-tagged cIAP1 BIR3 domain (260 to 352) (unknown origin) after 45 mins by TR-FRET Assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA2439931 | B | Displacement of AVPIAQKSEK (epsilon-biotin)-OH from 6xhistidine-thrombin-TEV-tagged cIAP1 BIR2 domain (174 to 256) (unknown origin) after 45 mins by TR-FRET Assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA2439932 | A | Fraction unbound in human | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA2439933 | A | Fraction unbound in mouse | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA2439934 | A | Tmax in C57 mouse at 10 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature |
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