#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA2439451	Functional	Induction of sensitization of human SW620 cells to conatumumab-induced apoptosis assessed as cell viability at 2.5 uM after 5 days by MTS assay	Homo sapiens	2	ALA2434833	cell-based format	Scientific Literature
2.	ALA2439453	ADME	Drug uptake in tumor of nude mouse xenografted with human LOX cells at 200 mg/kg, po measured at 8 hrs	Mus musculus	1	ALA2434833	organism-based format	Scientific Literature
3.	ALA2439455	ADME	Plasma concentration in nude mouse xenografted with human LOX cells at 200 mg/kg, po measured at 8 hrs	Mus musculus	1	ALA2434833	organism-based format	Scientific Literature
4.	ALA2439457	Functional	In vivo inhibition of XIAP BIR2 domain in human LOX cells xenografted in nude mouse assessed as potentiation of conatumumab-induced caspase 3/7 activity at 200 mg/kg, po after 8 hrs by Western blot analysis	Mus musculus	1	ALA2434833	organism-based format	Scientific Literature
5.	ALA2439459	Functional	In vivo inhibition of XIAP BIR2 domain in human LOX cells xenografted in nude mouse assessed as increase in caspase 3/7 activity at 200 mg/kg, po after 8 hrs by Western blot analysis	Mus musculus	1	ALA2434833	organism-based format	Scientific Literature
6.	ALA2439460	Binding	Inhibition of cIAP1/2 in human MDA-MB-231 cells assessed as induction of TNFalpha level at 0.37 to 3.3 uM after 19 hrs by ELISA	Homo sapiens	2	ALA2434833	cell-based format	Scientific Literature
7.	ALA2439462	Functional	Potentiation of conatumumab-induced apoptosis in human Capan1 cells at 2.5 uM after 5 days by MTS assay	Homo sapiens	2	ALA2434833	cell-based format	Scientific Literature
8.	ALA2439463	Functional	Potentiation of conatumumab-induced apoptosis in human SKMES1 cells at 2.5 uM after 5 days by MTS assay	Homo sapiens	2	ALA2434833	cell-based format	Scientific Literature
9.	ALA2439464	Functional	Potentiation of conatumumab-induced apoptosis in human U118MG cells at 2.5 uM after 5 days by MTS assay	Homo sapiens	2	ALA2434833	cell-based format	Scientific Literature
10.	ALA2439465	Functional	Induction of sensitization of human AGS cells to conatumumab-induced apoptosis assessed as cell viability at 2.5 uM after 5 days by MTS assay	Homo sapiens	2	ALA2434833	cell-based format	Scientific Literature
11.	ALA2439466	Functional	Induction of sensitization of human PC3 cells to conatumumab-induced apoptosis assessed as cell viability at 2.5 uM after 5 days by MTS assay	Homo sapiens	2	ALA2434833	cell-based format	Scientific Literature
12.	ALA2439467	Functional	Induction of sensitization of human SW620 cells to conatumumab-induced apoptosis assessed as cell viability after 5 days by MTS assay	Homo sapiens	2	ALA2434833	cell-based format	Scientific Literature
13.	ALA2439927	Functional	Induction of apoptosis in human SW620 cells assessed as cell viability at 0.37 to 10 uM after 5 days by MTS assay	Homo sapiens	1	ALA2434833	cell-based format	Scientific Literature
14.	ALA2439928	Binding	Inhibition of GST-tagged full length XIAP BIR2 domain-mediated caspase 3/7 cleavage in human HeLa S3 cell lysates assessed as cleavage of Ac-DEVD-AFC after 4 hrs in presence of cytochrome C and dATP	Homo sapiens	1	ALA2434833	single protein format	Scientific Literature
15.	ALA2439929	Binding	Selectivity ratio of IC50 for 6xhistidine-thrombin-TEV-tagged cIAP1 BIR2 domain (174 to 256) (unknown origin) to IC50 for 6xhistidine-thrombin-TEV-tagged XIAP BIR2 domain (124 to 240) (unknown origin)	Homo sapiens	1	ALA2434833	assay format	Scientific Literature
16.	ALA2439930	Binding	Displacement of AVPIAQKSEK (epsilon-biotin)-OH from 6xhistidine-thrombin-TEV-tagged cIAP1 BIR3 domain (260 to 352) (unknown origin) after 45 mins by TR-FRET Assay	Homo sapiens	1	ALA2434833	single protein format	Scientific Literature
17.	ALA2439931	Binding	Displacement of AVPIAQKSEK (epsilon-biotin)-OH from 6xhistidine-thrombin-TEV-tagged cIAP1 BIR2 domain (174 to 256) (unknown origin) after 45 mins by TR-FRET Assay	Homo sapiens	1	ALA2434833	single protein format	Scientific Literature
18.	ALA2439932	ADME	Fraction unbound in human	Homo sapiens	2	ALA2434833	organism-based format	Scientific Literature
19.	ALA2439933	ADME	Fraction unbound in mouse	Mus musculus	2	ALA2434833	organism-based format	Scientific Literature
20.	ALA2439934	ADME	Tmax in C57 mouse at 10 mg/kg, po	Mus musculus	2	ALA2434833	organism-based format	Scientific Literature