| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2443900 | B | Binding affinity to rat LBD of GluA2 receptor L483Y and N754S mutant at 243 uM by isothermal titration calorimetry analysis | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 2. | ALA2443905 | B | Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluorescence assay relative to AMPA | Rattus norvegicus | 7 | assay format | Scientific Literature | ||
| 3. | ALA2443906 | B | Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluorescence assay | Rattus norvegicus | 7 | assay format | Scientific Literature | ||
| 4. | ALA2443907 | B | Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as concentration required to 2 fold increase of AMPA-induced membrane depolarization by fluorescence assay | Rattus norvegicus | 7 | assay format | Scientific Literature | ||
| 5. | ALA3387343 | B | Binding affinity to GluA2-LBD-L483Y-N754S complex (unknown origin) by isothermal titration calorimetry | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 6. | ALA3387344 | B | Potentiation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as concentration required to 2-fold increase in AMPA-induced membrane depolarization by microplate reader | Rattus norvegicus | 9 | cell membrane format | Scientific Literature | ||
| 7. | ALA3387345 | B | Positive allosteric modulation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as maximal increase in AMPA-induced membrane depolarization normalized to AMPA-evoked response by microplate reader | Rattus norvegicus | 9 | cell membrane format | Scientific Literature | ||
| 8. | ALA3387346 | B | Positive allosteric modulation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as increase in AMPA-induced membrane depolarization by microplate reader | Rattus norvegicus | 9 | cell membrane format | Scientific Literature | ||
| 9. | ALA3387347 | B | Positive allosteric modulation of AMPA receptor in rat hippocampal slice assessed as increase in AMPA-mediated presynaptic noradrenaline release | Rattus norvegicus | 9 | tissue-based format | Scientific Literature | ||
| 10. | ALA4033578 | B | Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calcium flux by fluo-4/AM dye-based fluorescence assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 11. | ALA4033579 | B | Induction of dimerization of rat N-terminal His-tagged GluA2-LBD-N775S mutant expressed in Escherichia coli Origami B (DE3) assessed as intrinsic binding constant by small-angle X-ray scattering method | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 12. | ALA4725212 | T | Incucyte cell viability with HEK293T | Homo sapiens | 1,713 | cell-based format | EUbOPEN Chemogenomic Library | ||
| 13. | ALA4725213 | T | Incucyte cell viability with human fibroblast | Homo sapiens | 1,718 | cell-based format | EUbOPEN Chemogenomic Library | ||
| 14. | ALA4725214 | T | Incucyte cell viability with U2OS | Homo sapiens | 1,712 | cell-based format | EUbOPEN Chemogenomic Library |
The page will load shortly, Thanks for your patience!