| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2443901 | B | Positive allosteric modulation of GluA2 receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as concentration required to 2 fold increase of AMPA-induced membrane depolarization by voltage clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA2443905 | B | Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluorescence assay relative to AMPA | Rattus norvegicus | 7 | assay format | Scientific Literature | ||
| 3. | ALA2443906 | B | Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as increase of AMPA-induced membrane depolarization by fluorescence assay | Rattus norvegicus | 7 | assay format | Scientific Literature | ||
| 4. | ALA2443907 | B | Positive allosteric modulation of GluA2 receptor in rat embryonic cortex neuron assessed as concentration required to 2 fold increase of AMPA-induced membrane depolarization by fluorescence assay | Rattus norvegicus | 7 | assay format | Scientific Literature | ||
| 5. | ALA3387344 | B | Potentiation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as concentration required to 2-fold increase in AMPA-induced membrane depolarization by microplate reader | Rattus norvegicus | 9 | cell membrane format | Scientific Literature | ||
| 6. | ALA3387345 | B | Positive allosteric modulation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as maximal increase in AMPA-induced membrane depolarization normalized to AMPA-evoked response by microplate reader | Rattus norvegicus | 9 | cell membrane format | Scientific Literature | ||
| 7. | ALA3387346 | B | Positive allosteric modulation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as increase in AMPA-induced membrane depolarization by microplate reader | Rattus norvegicus | 9 | cell membrane format | Scientific Literature | ||
| 8. | ALA3387347 | B | Positive allosteric modulation of AMPA receptor in rat hippocampal slice assessed as increase in AMPA-mediated presynaptic noradrenaline release | Rattus norvegicus | 9 | tissue-based format | Scientific Literature | ||
| 9. | ALA3387901 | B | Positive allosteric modulation of AMPA receptor in rat hippocampal slice assessed as area of AMPA-mediated presynaptic excitatory postsynaptic field potential in CA1 area at 3 uM | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA3387902 | B | Positive allosteric modulation of AMPA receptor in rat hippocampal slice assessed as area of AMPA-mediated presynaptic excitatory postsynaptic field potential in CA1 area at 10 uM | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA3387903 | B | Positive allosteric modulation of AMPA receptor in rat hippocampal slice assessed as amplitude of AMPA-mediated presynaptic excitatory postsynaptic field potential in CA1 area at 3 uM | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA3387904 | B | Positive allosteric modulation of AMPA receptor in rat hippocampal slice assessed as amplitude of AMPA-mediated presynaptic excitatory postsynaptic field potential in CA1 area at 10 uM | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA3387905 | B | Positive allosteric modulation of AMPA receptor in rat hippocampal slice assessed as half-width of AMPA-mediated presynaptic excitatory postsynaptic field potential in CA1 area at 3 uM | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA3387906 | B | Positive allosteric modulation of AMPA receptor in rat hippocampal slice assessed as half-width of AMPA-mediated presynaptic excitatory postsynaptic field potential in CA1 area at 10 uM | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA3387907 | A | Drug uptake in mouse brain at 3 mg/kg, po qd after 20 mins by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3387908 | A | Drug uptake in mouse plasma at 3 mg/kg, po qd after 20 mins by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3389204 | A | Ratio of drug level in mouse brain to plasma at 3 mg/kg, po qd after 20 mins by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3389205 | F | Potentiation of high-frequency stimulation-induced synaptic response in Wistar rat hippocampal dentate gyrus assessed as excitatory postsynaptic field potential at 3 mg/kg, ip after 3 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3389206 | F | Potentiation of high-frequency stimulation-induced synaptic response in Wistar rat hippocampal dentate gyrus assessed as excitatory postsynaptic field potential at 10 mg/kg, ip after 3 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3389742 | F | Potentiation of high-frequency stimulation-induced synaptic response in Wistar rat hippocampal dentate gyrus assessed as increase in long-term potentiation at 3 mg/kg, ip after 1 hr | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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