# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2446433 | Functional | Reduction in triglyceride level in marmosets at 30 mg/kg/day, po for 7 days | marmosets | 4 | ALA2439948 | organism-based format | Scientific Literature | |
2. | ALA2446434 | Functional | Reduction in HDL cholesterol level in marmosets at 30 mg/kg/day, po for 7 days | marmosets | 4 | ALA2439948 | organism-based format | Scientific Literature | |
3. | ALA2446435 | Functional | Reduction in non-HDL cholesterol level in marmosets at 30 mg/kg/day, po for 7 days | marmosets | 4 | ALA2439948 | organism-based format | Scientific Literature | |
4. | ALA2446436 | Functional | Reduction in total cholesterol level in marmosets at 30 mg/kg/day, po for 7 days | marmosets | 4 | ALA2439948 | organism-based format | Scientific Literature | |
5. | ALA2446438 | Functional | Inhibition of cholesterol synthesis in Wistar rat at 1 mg/kg, po administered as single dose prior to [14C]mevalonolactone injection measured after 7 hrs by liquid scintillation counting | Rattus norvegicus | 5 | ALA2439948 | organism-based format | Scientific Literature | |
6. | ALA2446439 | Functional | Inhibition of cholesterol synthesis in Wistar rat at 1 mg/kg, po administered as single dose prior to [14C]mevalonolactone injection measured after 4 hrs by liquid scintillation counting | Rattus norvegicus | 5 | ALA2439948 | organism-based format | Scientific Literature | |
7. | ALA2446440 | Functional | Inhibition of cholesterol synthesis in Wistar rat at 1 mg/kg, po administered as single dose prior to [14C]mevalonolactone injection measured after 1 hr by liquid scintillation counting | Rattus norvegicus | 5 | ALA2439948 | organism-based format | Scientific Literature | |
8. | ALA2446441 | Functional | Inhibition of cholesterol synthesis in rat hepatocytes assessed as formation of cholesterol using [14C]mevalonolactone as substrate after 1 hr by liquid scintillation counting | Rattus norvegicus | 9 | ALA2439948 | cell-based format | Scientific Literature | |
9. | ALA2446442 | Binding | Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometry | Rattus norvegicus | 9 | ALA2439948 | assay format | Scientific Literature |