| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2444970 | F | Ex vivo antihuntington's disease activity in R6/2 transgenic mouse assessed as decrease of cerebral ventricles size at 3 to 30 mg/kg, po qd measured after 8 weeks by MRI analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2444971 | F | Antihuntington's disease activity in R6/2 transgenic mouse assessed as decrease of cerebral ventricles size at 3 to 30 mg/kg, po qd measured after 8 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2444972 | F | Antihuntington's disease activity in R6/2 transgenic mouse assessed as prevention of ventricular volume enlargment at 3 to 30 mg/kg, po qd measured after 8 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2444973 | T | Toxicity in R6/2 transgenic mouse assessed as mortality at 1 to 30 mg/kg, po qd | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2444974 | T | Toxicity in R6/2 transgenic mouse assessed as motor impairment at 1 to 30 mg/kg, po qd | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA2445801 | T | Genotoxicity in Salmonella typhimurium by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA2445802 | F | Antihuntington's disease activity in R6/2 transgenic mouse assessed as decrease in body weight at 10 to 30 mg/kg, po qd | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA2445803 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA2445804 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA2445805 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA2445806 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA2445807 | A | Inhibition of CYP3A4 (unknown origin) using nifedipine as substrate | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA2445808 | B | Inhibition of human ERG up to 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA2445809 | A | Inhibition of CYP3A4 (unknown origin) using testosterone as substrate | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA2445810 | A | Cytotoxicity in Sprague-Dawley rat striatal neurons | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
| 16. | ALA2445811 | A | Ratio of drug level in brain to plasma in CD1 mouse at 5 mg/kg, po and iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA2445812 | A | Cytoprotective activity in rat PC12 cells after 72 hrs by LDH release assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA2445813 | B | Inhibition of wild type huntingtin 171-18Q-mediated cell death in Sprague-Dawley rat striatal neurons at 1 to 30 uM by NeuN-positive cell counting assay | Rattus norvegicus | 4 | single protein format | Scientific Literature | ||
| 19. | ALA2445814 | B | Inhibition of huntingtin 171-82Q mutant-mediated cell death in Sprague-Dawley rat striatal neurons at 10 to 30 uM by NeuN-positive cell counting assay | Rattus norvegicus | 4 | assay format | Scientific Literature | ||
| 20. | ALA2445815 | P | Kinetic solubility of the compound at pH 7.4 | 18 | small-molecule physicochemical format | Scientific Literature |
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