# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3705819 | Binding | Biacore Assay: The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain was immobilized by capture of his tag by the Ab previously covalently bound to the chip (CM5) surface. A short cross-linking procedure after HSP90 binding was necessary in order to obtained a more stable signal.The compounds were analyzed using the following running buffer: 20 mM Tris/HCl pH 7.6, 150 mM KCl, 5 mM MgCl2, 0.05% P20 and 1% DMSO. The flow rate was 50 ul/min with and association time of 60 seconds.The cpds were diluted in running buffer from 100x stock solution; the different conc injected were obtained from a sequential dilution in order to have the same DMSO conc. in each sample and avoid any solvent correction.A series of 5 sequential injections of increasing concentrations of compound were performed and the results were analyzed using a method reported in literature (Robert Karlsson et al). | Homo sapiens | 18 | ALA3638478 | single protein format | BindingDB Database | |
2. | ALA2443721 | Binding | Inhibition of ZAP70 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
3. | ALA2443722 | Binding | Inhibition of VEGFR3 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
4. | ALA2443723 | Binding | Inhibition of VEGFR2 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
5. | ALA2443724 | Binding | Inhibition of TYK2 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
6. | ALA2443725 | Binding | Inhibition of TRKA (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
7. | ALA2443976 | Binding | Inhibition of SYK (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
8. | ALA2443977 | Binding | Inhibition of SULU1 (unknown origin) | Homo sapiens | 4 | ALA2439976 | assay format | Scientific Literature | |
9. | ALA2443978 | Binding | Inhibition of RET (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
10. | ALA2443979 | Binding | Inhibition of PLK1 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
11. | ALA2443980 | Binding | Inhibition of PKCbeta2 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
12. | ALA2443981 | Binding | Inhibition of PKAalpha (unknown origin) | Homo sapiens | 4 | ALA2439976 | assay format | Scientific Literature | |
13. | ALA2443982 | Binding | Inhibition of PIM2 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
14. | ALA2443983 | Binding | Inhibition of PIM1 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
15. | ALA2443984 | Binding | Inhibition of PDK1 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
16. | ALA2443985 | Binding | Inhibition of PERK (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
17. | ALA2443986 | Binding | Inhibition of PDGFRbeta (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
18. | ALA2443987 | Binding | Inhibition of PAK4 (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
19. | ALA2443988 | Binding | Inhibition of P38alpha (unknown origin) | Homo sapiens | 4 | ALA2439976 | single protein format | Scientific Literature | |
20. | ALA2443989 | Binding | Inhibition of NIM (unknown origin) | Homo sapiens | 4 | ALA2439976 | assay format | Scientific Literature |
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