# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2445736 | Toxicity | Cardiotoxicity in isolated rabbit left ventricular wedge model assessed as torsade de pointes score at 0.3 to 1 uM | Oryctolagus cuniculus | 1 | ALA2440083 | tissue-based format | Scientific Literature | |
2. | ALA2445971 | Toxicity | Cardiotoxicity in isolated rabbit left ventricular wedge model assessed as increase in QT interval at 1 uM | Oryctolagus cuniculus | 1 | ALA2440083 | tissue-based format | Scientific Literature | |
3. | ALA2445972 | Toxicity | Cardiotoxicity in isolated rabbit left ventricular wedge model assessed as increase in Tp-e interval at 1 uM | Oryctolagus cuniculus | 2 | ALA2440083 | tissue-based format | Scientific Literature | |
4. | ALA2445975 | Binding | Inhibition of human Cav 1.2 ion channel expressed in HEK293 cells by whole-cell patch clamp technique | Homo sapiens | 2 | ALA2440083 | cell-based format | Scientific Literature | |
5. | ALA2445976 | Binding | Inhibition of human Nav 1.5 tonic ion channel expressed in HEK293 cells by whole-cell patch clamp technique | Homo sapiens | 2 | ALA2440083 | cell-based format | Scientific Literature | |
6. | ALA2445977 | Binding | Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp technique | Homo sapiens | 2 | ALA2440083 | cell-based format | Scientific Literature | |
7. | ALA2445978 | Binding | Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp technique | Homo sapiens | 2 | ALA2440083 | cell-based format | Scientific Literature | |
8. | ALA2445981 | Binding | Selectivity ratio of EC50 for human mu opioid receptor expressed in HEK293 cells over EC50 for human delta opioid receptor expressed in HEK293 cells | Homo sapiens | 2 | ALA2440083 | cell-based format | Scientific Literature | |
9. | ALA2445982 | Binding | Selectivity ratio of EC50 for human mu opioid receptor expressed in HEK293 cells over EC50 for human kappa opioid receptor expressed in HEK293 cells | Homo sapiens | 2 | ALA2440083 | cell-based format | Scientific Literature | |
10. | ALA2445983 | Functional | Agonist activity at human delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescence assay | Homo sapiens | 2 | ALA2440083 | cell-based format | Scientific Literature | |
11. | ALA2445984 | Functional | Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescence assay | Homo sapiens | 2 | ALA2440083 | cell-based format | Scientific Literature | |
12. | ALA2445985 | Toxicity | Toxicity in mouse fecal boli accumulation model assessed as fecal boli production at equianalgesic dose, sc after 4 hrs relative to morphine | Mus musculus | 1 | ALA2440083 | organism-based format | Scientific Literature | |
13. | ALA2445986 | Toxicity | Toxicity in mouse glass bead model assessed as retention time of colonic motility at 3 mg/kg, sc | Mus musculus | 1 | ALA2440083 | organism-based format | Scientific Literature | |
14. | ALA2445988 | Functional | Analgesic effect in mouse at 3 mg/kg, sc after 30 mins by hot plate assay | Mus musculus | 1 | ALA2440083 | organism-based format | Scientific Literature | |
15. | ALA2445990 | Functional | Analgesic effect in sc dosed mouse by hot plate assay | Mus musculus | 1 | ALA2440083 | organism-based format | Scientific Literature | |
16. | ALA2445991 | Binding | Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as beta-arrestin recruitment by chemiluminescence assay relative to morphine | Homo sapiens | 35 | ALA2440083 | cell-based format | Scientific Literature | |
17. | ALA2445992 | Binding | Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as beta-arrestin recruitment by chemiluminescence assay | Homo sapiens | 36 | ALA2440083 | cell-based format | Scientific Literature | |
18. | ALA2445993 | Functional | Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescence assay relative to morphine | Homo sapiens | 35 | ALA2440083 | cell-based format | Scientific Literature | |
19. | ALA2445994 | Functional | Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescence assay | Homo sapiens | 36 | ALA2440083 | cell-based format | Scientific Literature |