| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3783536 | F | Antiparasitic activity against suramin-sensitive trypomastigote stage of Trypanosoma brucei rhodesiense squib-427 infected in human MRC5 cells after 4 days by Alamar blue staining based fluorimetric analysis | Trypanosoma brucei rhodesiense | 19 | ALA3779855 | organism-based format | Scientific Literature | |
| 2. | ALA3782748 | B | Inhibition of human recombinant PTP-1B using IR5 insulin receptor residues as substrate at 10 uM after 30 mins by malachite green assay | Homo sapiens | 16 | ALA3779790 | single protein format | Scientific Literature | |
| 3. | ALA3811612 | F | Antiangiogenic activity against HUVEC assessed as inhibition of total tube length at 10 uM after 16 hrs by inverted microscopy | Homo sapiens | 3 | ALA3808299 | cell-based format | Scientific Literature | |
| 4. | ALA3811614 | F | Antiangiogenic activity against HUVEC assessed as inhibition of total tube junctions at 10 uM after 16 hrs by inverted microscopy | Homo sapiens | 3 | ALA3808299 | cell-based format | Scientific Literature | |
| 5. | ALA3815623 | B | Competitive inhibition of human NPP1 expressed in African green monkey COS7 cells using ATP as substrate after 20 mins by Michaelis-Menten plot analysis | Homo sapiens | 2 | ALA3813632 | cell-based format | Scientific Literature | |
| 6. | ALA3855682 | B | Inhibition of wild type His-tagged translin/trax E126A mutant (unknown origin) coexpressed in Escherichia coli BL21 cells using RNase Alert as substrate at 30 uM incubated for 10 mins prior to substrate addition monitored over 60 mins by fluorescence assay | Homo sapiens | 19 | ALA3853344 | cell-based format | Scientific Literature | |
| 7. | ALA3856370 | F | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei S16 assessed as inhibition of proliferation measured after 72 hrs by alamarBlue assay | Trypanosoma brucei brucei | 32 | ALA3856184 | assay format | Scientific Literature | |
| 8. | ALA3859765 | F | Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 VSG 221 [TetR T7RNAP] transgenic bloodstream forms assessed as reduction in cell viability after 48 hrs by alamar blue assay | Trypanosoma brucei brucei | 53 | ALA3856280 | assay format | Scientific Literature | |
| 9. | ALA3859766 | B | Inhibition of Escherichia coli GroEL/GroES expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preincubated for 10 mins followed by ATP addition measured after 20 to 40 mins by fluorescence based assay | Escherichia coli | 53 | ALA3856280 | assay format | Scientific Literature | |
| 10. | ALA3859767 | A | Inhibition of human mitochondrial HSP60/HSP10 expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preincubated for 10 mins followed by ATP addition measured after 40 to 60 mins by fluorescence based assay | Homo sapiens | 53 | ALA3856280 | assay format | Scientific Literature | |
| 11. | ALA3859768 | B | Inhibition of Escherichia coli GroEL/GroES-ATPase activity expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preincubated for 10 mins followed by ATP addition measured after 20 to 40 mins by malachite green dye based fluorescence assay | Escherichia coli | 53 | ALA3856280 | assay format | Scientific Literature | |
| 12. | ALA3859769 | A | Inhibition of human mitochondrial HSP60/HSP10-ATPase activity expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preincubated for 10 mins followed by ATP addition measured after 40 to 60 mins by malachite green dye based fluorescence assay | Homo sapiens | 53 | ALA3856280 | assay format | Scientific Literature | |
| 13. | ALA3859770 | T | Cytotoxicity against human THLE3 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay | Homo sapiens | 53 | ALA3856280 | cell-based format | Scientific Literature | |
| 14. | ALA3859771 | T | Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay | Homo sapiens | 53 | ALA3856280 | cell-based format | Scientific Literature | |
| 15. | ALA3859772 | A | Inhibition of pig heart native MDH reporter reaction after 20 to 40 mins by fluorescence based assay | Sus scrofa | 53 | ALA3856280 | assay format | Scientific Literature | |
| 16. | ALA3863230 | B | Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by scintillation proximity assay | Homo sapiens | 86 | ALA3862005 | assay format | Scientific Literature | |
| 17. | ALA3863231 | B | Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis | Homo sapiens | 86 | ALA3862005 | assay format | Scientific Literature | |
| 18. | ALA3864312 | F | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei GUTat 3.1 after 72 hrs by Alamar blue assay | Trypanosoma brucei brucei | 2 | ALA3864127 | assay format | Scientific Literature | |
| 19. | ALA3999709 | B | Inhibition of human Sirt1 expressed in bacteria at 10 uM using fluorophorelabeled substrate peptide after 15 mins by fluorescence assay relative to control | Homo sapiens | 6 | ALA3997827 | assay format | Scientific Literature | |
| 20. | ALA4011663 | A | Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate transport preincubated for 10 mins prior to ATP addition measured after 15 mins in presence of [3H]-taurocholate by topcount based membrane vesicle transport assay | Homo sapiens | 216 | ALA4011581 | assay format | Scientific Literature |
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