| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3090663 | F | Antileishmanial activity against promastigote stage of Leishmania infantum assessed as alteration in nuclear DNA at IC50 after 48 hrs by propidium iodide staining-based confocal laser scanning microscopic analysis | Leishmania infantum | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA3090664 | F | Antileishmanial activity against promastigote stage of Leishmania infantum assessed as alteration in kinetoplast DNA at IC50 after 48 hrs by propidium iodide staining-based confocal laser scanning microscopic analysis | Leishmania infantum | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA3090665 | B | Binding affinity to beta-tubulin in promastigote stage of Leishmania infantum assessed as structure disorganization at IC50 after 48 hrs by confocal laser scanning microscopic analysis | Leishmania infantum | 1 | assay format | Scientific Literature | ||
| 4. | ALA3090672 | T | Toxicity in BALB/c mouse infected with promastigote stage of Leishmania infantum MCAN/ES/96/BCN150 assessed as hair loss at 10 mg/kg, ip qd administered for 5 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA3090709 | T | Toxicity in BALB/c mouse infected with promastigote stage of Leishmania infantum MCAN/ES/96/BCN150 assessed as gross weight loss at 10 mg/kg, ip qd administered for 5 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA3090711 | F | Leishmanicidal activity against promastigote stage of Leishmania infantum MCAN/ES/96/BCN150 infected in BALB/c mouse assessed as reduction of parasite burden in liver at 10 mg/kg, ip qd administered for 5 days measured after 7 days by limiting dilution assay relative to untreated control | Leishmania infantum | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA3090712 | F | Leishmanicidal activity against promastigote stage of Leishmania infantum MCAN/ES/96/BCN150 infected in BALB/c mouse assessed as reduction of parasite burden in liver at 5 mg/kg, ip qd administered for 5 days measured after 7 days by limiting dilution assay relative to untreated control | Leishmania infantum | 5 | organism-based format | Scientific Literature | ||
| 8. | ALA3090713 | F | Leishmanicidal activity against promastigote stage of Leishmania infantum MCAN/ES/96/BCN150 infected in BALB/c mouse assessed as reduction of parasite burden in spleen at 10 mg/kg, ip qd administered for 5 days measured after 7 days by limiting dilution assay relative to untreated control | Leishmania infantum | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA3090714 | F | Leishmanicidal activity against promastigote stage of Leishmania infantum MCAN/ES/96/BCN150 infected in BALB/c mouse assessed as reduction of parasite burden in spleen at 5 mg/kg, ip qd administered for 5 days measured after 7 days by limiting dilution assay relative to untreated control | Leishmania infantum | 5 | organism-based format | Scientific Literature | ||
| 10. | ALA3090715 | F | Trypanocidal activity against intracellular amastigote stage of Trypanosoma cruzi CL-B5 infected in mouse NCTC-929 cells assessed as reduction of parasite load after 7 days by resazurin dye-based fluorometric analysis | Trypanosoma cruzi | 9 | organism-based format | Scientific Literature | ||
| 11. | ALA3090716 | F | Leishmanicidal activity against intracellular amastigote stage of Leishmania amazonensis MHOM/Br/79/Maria infected in mouse J774 cells assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania amazonensis | 9 | organism-based format | Scientific Literature | ||
| 12. | ALA3090717 | F | Leishmanicidal activity against intracellular amastigote stage of Leishmania infantum MCAN/ES/96/BCN150 infected in mouse J774 cells assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania infantum | 9 | organism-based format | Scientific Literature | ||
| 13. | ALA3090718 | F | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for extracellular promastigote stage of Leishmania amazonensis MHOM/Br/79/Maria | 5 | cell-based format | Scientific Literature | |||
| 14. | ALA3090719 | F | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for extracellular promastigote stage of Leishmania guyanensis 141/93 | 5 | cell-based format | Scientific Literature | |||
| 15. | ALA3090720 | F | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for extracellular promastigote stage of Leishmania braziliensis 2903 | 5 | cell-based format | Scientific Literature | |||
| 16. | ALA3090721 | F | Selectivity index, ratio of CC50 for mouse J774 cells to IC50 for extracellular promastigote stage of Leishmania infantum MCAN/ES/96/BCN150 | 5 | cell-based format | Scientific Literature | |||
| 17. | ALA3090723 | A | Cytotoxicity against mouse NCTC-929 cells assessed as reduction of cell viability after 24 hrs by resazurin dye-based fluorometric analysis | Mus musculus | 29 | cell-based format | Scientific Literature | ||
| 18. | ALA3090724 | A | Cytotoxicity against mouse J774 cells assessed as reduction of cell viability after 24 hrs by resazurin dye-based fluorometric analysis | Mus musculus | 29 | cell-based format | Scientific Literature | ||
| 19. | ALA3090725 | F | Trypanocidal activity against extracellular epimastigote stage of Trypanosoma cruzi CL-B5 assessed as reduction of parasite load after 72 hrs by resazurin dye-based fluorometric analysis | Trypanosoma cruzi | 28 | organism-based format | Scientific Literature | ||
| 20. | ALA3090726 | F | Leishmanicidal activity against extracellular promastigote stage of Leishmania amazonensis MHOM/Br/79/Maria assessed as reduction of parasite load after 48 hrs by resazurin dye-based fluorometric analysis | Leishmania amazonensis | 28 | organism-based format | Scientific Literature |
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