# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3090125 | ADME | Drug level in C57BL/6 mouse brain at 30 mg/kg, ip after 12 hrs | Mus musculus | 2 | ALA3085701 | organism-based format | Scientific Literature | |
2. | ALA3090127 | ADME | Drug level in C57BL/6 mouse brain at 30 mg/kg, ip after 2 hrs | Mus musculus | 2 | ALA3085701 | organism-based format | Scientific Literature | |
3. | ALA3090129 | ADME | Drug level in C57BL/6 mouse brain at 30 mg/kg, ip after 30 mins | Mus musculus | 2 | ALA3085701 | organism-based format | Scientific Literature | |
4. | ALA3090131 | ADME | Plasma concentration in C57BL/6 mouse at 30 mg/kg, ip after 12 hrs | Mus musculus | 2 | ALA3085701 | organism-based format | Scientific Literature | |
5. | ALA3090132 | ADME | Plasma concentration in C57BL/6 mouse at 30 mg/kg, ip after 2 hrs | Mus musculus | 2 | ALA3085701 | organism-based format | Scientific Literature | |
6. | ALA3090135 | ADME | Plasma concentration in C57BL/6 mouse at 30 mg/kg, ip after 30 mins | Mus musculus | 2 | ALA3085701 | organism-based format | Scientific Literature | |
7. | ALA3090136 | Functional | Antiviral activity against Fort Morgan virus infected in human BE(2)-C cells assessed as reduction of viral titer at 25 uM after 24 hrs by plaque reduction assay (Rvb = 47.1 +/- 10.5 x 10'6 pfu/ml) | Fort Morgan virus | 12 | ALA3085701 | cell-based format | Scientific Literature | |
8. | ALA3090137 | ADME | Cytotoxicity against human BE(2)-C cells assessed as cell viability at 25 uM after 24 hrs by MTT assay relative to control | Homo sapiens | 12 | ALA3085701 | cell-based format | Scientific Literature | |
9. | ALA3090138 | Functional | Antiviral activity against Western equine encephalomyelitis virus infected in human BE(2)-C cells assessed as reduction of viral titer at 25 uM after 24 hrs by plaque reduction assay (Rvb = 25.7 +/- 5.2 x 10'6 pfu/ml) | Western equine encephalitis virus | 12 | ALA3085701 | cell-based format | Scientific Literature | |
10. | ALA3090139 | Physicochemical | Kinetic solubility of the compound | 15 | ALA3085701 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA3090142 | ADME | Half life in Balb-C mouse liver microsomes | Mus musculus | 8 | ALA3085701 | microsome format | Scientific Literature | |
12. | ALA3090143 | ADME | Effective permeability of the compound at pH 7.4 by PAMPA method | 20 | ALA3085701 | assay format | Scientific Literature | ||
13. | ALA3090144 | ADME | Cytotoxicity against human BE(2)-C cells after 18 to 20 hrs by MTT assay | Homo sapiens | 47 | ALA3085701 | cell-based format | Scientific Literature | |
14. | ALA3090145 | Functional | Antiviral activity against Western equine encephalomyelitis virus infected in human BE(2)-C cells assessed as inhibition of viral RNA replication after 18 to 20 hrs by luciferase reporter gene assay | Western equine encephalitis virus | 51 | ALA3085701 | cell-based format | Scientific Literature | |
15. | ALA3090146 | ADME | Inhibition of human MDR1 expressed in MDCK2 cells assessed as increase of rhodamine 123 uptake at 30 uM up to 240 mins relative to control | Homo sapiens | 21 | ALA3085701 | cell-based format | Scientific Literature | |
16. | ALA3398842 | Functional | Antiviral activity against Western equine encephalomyelitis virus infected in human BE(2)-C cells assessed as inhibition of viral RNA replication after 18 to 20 hrs by luciferase reporter gene assay | Western equine encephalitis virus | 22 | ALA3396967 | cell-based format | Scientific Literature | |
17. | ALA3398843 | ADME | Cytotoxicity against human BE(2)-C cells after 18 to 20 hrs by MTT assay | Homo sapiens | 22 | ALA3396967 | cell-based format | Scientific Literature | |
18. | ALA3398844 | ADME | Effective permeability at pH 7.4 by BBB-PAMPA method | 11 | ALA3396967 | assay format | Scientific Literature | ||
19. | ALA3398845 | ADME | Inhibition of human MDR1 expressed in MDCK2 cells assessed as increase of rhodamine 123 uptake at 30 uM up to 240 mins relative to 5 uM tariquidar | Homo sapiens | 11 | ALA3396967 | cell-based format | Scientific Literature | |
20. | ALA3398847 | ADME | Half life in BALB/c mouse liver microsomes at 1 uM in presence of NADPH by HPLC-MS/MS method | Mus musculus | 11 | ALA3396967 | assay format | Scientific Literature |