# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3096354 | A | Clearance in human liver microsomes at 5 uM by LC-MS/MS analysis | Homo sapiens | 22 | assay format | Scientific Literature | ||
2. | ALA3096355 | A | Solubility of the compound in fasted state simulated intestinal fluid measured after overnight incubation by UV-HPLC analysis | 22 | assay format | Scientific Literature | |||
3. | ALA3096356 | B | Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assay | Homo sapiens | 22 | single protein format | Scientific Literature | ||
4. | ALA3096357 | B | Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 mins by IMAP fluorescence polarization assay | Homo sapiens | 22 | single protein format | Scientific Literature | ||
5. | ALA3096358 | F | Antiproliferative activity against human HCT116 cells assessed as cell viability after 96 hrs by cell counting kit-8 assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
6. | ALA3090547 | A | Oral bioavailability in cynomolgus monkey at 5 mg/kg | Macaca fascicularis | 2 | organism-based format | Scientific Literature | ||
7. | ALA3090623 | F | Antitumor activity against human HCT116 cells xenografted in BALB-nu/u mouse assessed as tumor growth inhibition at 100 mg/kg, po qd for 11 days relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
8. | ALA3090625 | A | Oral bioavailability in BALB-nu/u mouse at 100 mg/kg after 24 hrs by LC/MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
9. | ALA3090627 | A | AUC (0 to t) in BALB-nu/u mouse at 100 mg/kg, po after 24 hrs by LC/MS/MS analysis | Mus musculus | 6 | organism-based format | Scientific Literature | ||
10. | ALA3090629 | A | Drug metabolism in human liver microsomes assessed as formation of N-{3-[(6-chloro-7-hydroxy-4-methyl-2-oxo-2H-chromen-3-yl)methyl]phenyl}-N'-methylsulfamide | Homo sapiens | 1 | assay format | Scientific Literature | ||
11. | ALA3090630 | A | Drug metabolism in human liver microsomes assessed as formation of 6-chloro-4-methyl-3-(3-(N-methylsulfamoylamino)benzyl)-2-oxo-2H-chromen-7-yl hydroxymethyl(methyl)carbamate | Homo sapiens | 1 | assay format | Scientific Literature | ||
12. | ALA3090631 | A | Drug metabolism in human liver microsomes assessed as formation of dimethylcarbamic acid 6-chloro-4-methyl-2-oxo-3-[3-(sulfamoylamino)benzyl]-2H-chromen-7-yl ester | Homo sapiens | 1 | assay format | Scientific Literature | ||
13. | ALA3090632 | A | Permeability of the compound by PSR4p PAMPA | 16 | assay format | Scientific Literature | |||
14. | ALA3090851 | A | Intrinsic clearance in mouse liver microsomes at 5 uM after 60 mins by LC/MS/MS analysis | Mus musculus | 16 | microsome format | Scientific Literature | ||
15. | ALA3090852 | A | Intrinsic clearance in human liver microsomes at 5 uM after 60 mins by LC/MS/MS analysis | Homo sapiens | 16 | assay format | Scientific Literature | ||
16. | ALA3090853 | A | Solubility of the compound in FaSSIF at pH 6.5 by lyophilized solubility assay | 16 | assay format | Scientific Literature | |||
17. | ALA3090854 | B | Inhibition of ABL (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
18. | ALA3090855 | B | Inhibition of BRK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
19. | ALA3090856 | B | Inhibition of LCK (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
20. | ALA3090897 | B | Inhibition of LYN (unknown origin) after 90 mins by TR-FRET/IMAP fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature |