| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3088599 | F | Suppression of testosterone in plasma of rat at 1 nmol/h, sc measured after 6 days by radioimmunoassay | Rattus norvegicus | 1 | ALA3085624 | organism-based format | Scientific Literature | |
| 2. | ALA3088600 | F | Suppression of testosterone in plasma of rat at 1 nmol/h, sc measured after 13 days by radioimmunoassay | Rattus norvegicus | 2 | ALA3085624 | organism-based format | Scientific Literature | |
| 3. | ALA3088601 | A | Bioavailability in Sprague-Dawley rat at 1 mg/kg, sc | Rattus norvegicus | 1 | ALA3085624 | organism-based format | Scientific Literature | |
| 4. | ALA3088603 | A | Plasma concentration in Copenhagen rat at 2 nmol/h, sc measured after 6 days by radioimmunoassay | Rattus norvegicus | 1 | ALA3085624 | organism-based format | Scientific Literature | |
| 5. | ALA3088605 | F | Suppression of testosterone in plasma of Copenhagen rat at 2 nmol/h, sc measured after 6 days by radioimmunoassay | Rattus norvegicus | 1 | ALA3085624 | organism-based format | Scientific Literature | |
| 6. | ALA3088606 | F | Suppression of testosterone in plasma of Sprague-Dawley rat at 2 nmol/h, sc measured after 6 days by radioimmunoassay | Rattus norvegicus | 2 | ALA3085624 | organism-based format | Scientific Literature | |
| 7. | ALA3088607 | F | Induction of ovulation in immature Wistar rats assessed as increase in number of oocytes at 30 to 100 nmol/kg administered dorsally by stereomicroscopy | Rattus norvegicus | 1 | ALA3085624 | organism-based format | Scientific Literature | |
| 8. | ALA3088608 | A | Metabolic stability in mouse serum assessed as compound remaining at 0.1 mM after 1 hr by HPLC analysis | Mus musculus | 29 | ALA3085624 | assay format | Scientific Literature | |
| 9. | ALA3088609 | B | Binding affinity to rat KISS1R | Rattus norvegicus | 29 | ALA3085624 | single protein format | Scientific Literature | |
| 10. | ALA3088610 | B | Binding affinity to human KISS1R expressed in CHO cell membranes | Homo sapiens | 29 | ALA3085624 | cell-based format | Scientific Literature | |
| 11. | ALA3088611 | F | Agonist activity at recombinant human KISS1R expressed in CHO cells assessed as intracellular calcium mobilization incubated for 30 mins at 37 degC and 30 mins at room temperature by Fluo-4 NW staining-based FLIPR assay relative to Metastin (45 to 54) | Homo sapiens | 28 | ALA3085624 | cell-based format | Scientific Literature | |
| 12. | ALA3088612 | B | Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay | Homo sapiens | 6 | ALA3085624 | cell-based format | Scientific Literature | |
| 13. | ALA3376866 | F | Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay | Homo sapiens | 26 | ALA3352485 | cell-based format | Scientific Literature | |
| 14. | ALA3376867 | F | Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay | Rattus norvegicus | 26 | ALA3352485 | cell-based format | Scientific Literature | |
| 15. | ALA3376868 | F | Testosterone-suppressive activity in Crl:CD(SD) rat assessed as number of animal with plasma testosterone level below the limit of detection at 2 nmol/hr, sc through osmotic pumps measured after 6 days by RIA | Rattus norvegicus | 9 | ALA3352485 | organism-based format | Scientific Literature | |
| 16. | ALA3376869 | B | Displacement of radioligand from human KISS1R transfected in CHO cells | Homo sapiens | 26 | ALA3352485 | cell-based format | Scientific Literature | |
| 17. | ALA3376870 | B | Displacement of radioligand from rat KISS1R transfected in CHO cells | Rattus norvegicus | 26 | ALA3352485 | cell-based format | Scientific Literature | |
| 18. | ALA3376871 | F | Testosterone-suppressive activity in Crl:CD(SD) rat assessed as number of animal with plasma testosterone level below the limit of detection at 0.5 nmol/hr, sc through osmotic pumps measured after 6 days by RIA | Rattus norvegicus | 9 | ALA3352485 | organism-based format | Scientific Literature | |
| 19. | ALA3376872 | F | Testosterone-suppressive activity in Crl:CD(SD) rat assessed as number of animal with plasma testosterone level below the limit of detection at 0.3 nmol/hr, sc through osmotic pumps measured after 6 days by RIA | Rattus norvegicus | 9 | ALA3352485 | organism-based format | Scientific Literature | |
| 20. | ALA3376873 | F | Testosterone-suppressive activity in Crl:CD(SD) rat assessed as number of animal with plasma testosterone level below the limit of detection at 0.1 nmol/hr, sc through osmotic pumps measured after 6 days by RIA | Rattus norvegicus | 16 | ALA3352485 | organism-based format | Scientific Literature |
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