# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3089094 | Functional | Antiproliferative activity against mouse LLC cells at 50 uM by WST-1 assay | Mus musculus | 9 | ALA3085691 | cell-based format | Scientific Literature | |
2. | ALA3089095 | Binding | Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometry | Homo sapiens | 15 | ALA3085691 | cell-based format | Scientific Literature | |
3. | ALA3089096 | Binding | Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrate | Homo sapiens | 9 | ALA3085691 | single protein format | Scientific Literature | |
4. | ALA3872636 | Binding | Mixed competitive inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) in presence of varying concentration of L-tryptophan substrate after 30 mins | Homo sapiens | 1 | ALA3872206 | assay format | Scientific Literature | |
5. | ALA3872637 | Binding | Inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate after 30 mins in presence of catalase by methylene blue dye based assay | Homo sapiens | 11 | ALA3872206 | assay format | Scientific Literature | |
6. | ALA3872639 | Binding | Inhibition of recombinant human IDO2 expressed in human U87MG cells assessed as reduction in kynurenine formation using L-tryptophan as substrate after 6 hrs by spectrophotometry | Homo sapiens | 11 | ALA3872206 | cell-based format | Scientific Literature | |
7. | ALA3872641 | Binding | Reversible inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate after 30 mins | Homo sapiens | 9 | ALA3872206 | assay format | Scientific Literature | |
8. | ALA3872643 | Binding | Potency index, ratio of D-1-methyl-tryptophan IC50 to compound IC50 for recombinant human IDO2 expressed in human U87MG cells | Homo sapiens | 6 | ALA3872206 | cell-based format | Scientific Literature | |
9. | ALA4383515 | Binding | Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 mins | Homo sapiens | 11 | ALA4382205 | assay format | Scientific Literature | |
10. | ALA4383517 | Binding | Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 mins by Dixon plot analysis | Homo sapiens | 4 | ALA4382205 | assay format | Scientific Literature | |
11. | ALA4383518 | Binding | Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrs | Homo sapiens | 11 | ALA4382205 | cell-based format | Scientific Literature | |
12. | ALA4383519 | Binding | Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrs | Homo sapiens | 11 | ALA4382205 | cell-based format | Scientific Literature | |
13. | ALA4482780 | Binding | Uncompetitive inhibition of IDO1 (unknown origin) using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine by dixon plot analysis | Homo sapiens | 6 | ALA4482322 | single protein format | Patent Bioactivity Data | |
14. | ALA4482783 | Binding | Mixed competitive inhibition of human IDO2 using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine by dixon plot analysis | Homo sapiens | 1 | ALA4482322 | single protein format | Patent Bioactivity Data | |
15. | ALA4482785 | Binding | Inhibition of human IDO2 at 10 uM using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine relative to control | Homo sapiens | 11 | ALA4482322 | single protein format | Patent Bioactivity Data | |
16. | ALA4482786 | Binding | Inhibition of IDO1 (unknown origin) using L-tryptophan as substrate assessed as reduction in conversion of N-formyl kynurenine to kynurenine | Homo sapiens | 11 | ALA4482322 | single protein format | Patent Bioactivity Data | |
17. | ALA4482787 | Binding | Inhibition of human IDO2 using L-tryptophan as substrate assessed as reduction in conversion of N-formyl kynurenine to kynurenine | Homo sapiens | 11 | ALA4482322 | single protein format | Patent Bioactivity Data | |
18. | ALA4482789 | Binding | Inhibition of IDO1 in human U87MG cells in presence of L-tryptophan incubated for 24 h | Homo sapiens | 11 | ALA4482322 | cell-based format | Patent Bioactivity Data | |
19. | ALA4482790 | Binding | Inhibition of IDO2 (unknown origin) expressed in human U87MG cells in presence of L-tryptophan incubated for 24 h | Homo sapiens | 11 | ALA4482322 | cell-based format | Patent Bioactivity Data |