# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3091156 | A | Therapeutic index, ratio of ED80 for methacholine-induced bronchoconstriction in Dunkin-Hartley guinea pig to EC50 for reduction of pilocarpine-induced salivation in guinea pig | Cavia porcellus | 5 | organism-based format | Scientific Literature | ||
2. | ALA3091157 | T | Toxicity in guinea pig assessed as reduction of pilocarpine-induced salivation administered via intranasal administered for 4 hrs followed by pilocarpine challenge measured every 5 mins for 15 mins | Cavia porcellus | 10 | organism-based format | Scientific Literature | ||
3. | ALA3091158 | F | Inhibition of methacholine-induced bronchoconstriction in Dunkin-Hartley guinea pig administered via intratracheal/intranasal after 48 hrs relative to control | Cavia porcellus | 6 | organism-based format | Scientific Literature | ||
4. | ALA3091160 | F | Inhibition of methacholine-induced bronchoconstriction in Dunkin-Hartley guinea pig administered via intratracheal/intranasal after 2 to 4 hrs relative to control | Cavia porcellus | 12 | organism-based format | Scientific Literature | ||
5. | ALA3091161 | A | Half life in guinea pig lung administered via intratracheal instillation at 1 ug/kg by HPLC-MS analysis | Cavia porcellus | 18 | tissue-based format | Scientific Literature | ||
6. | ALA3091162 | B | Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contraction after 1 to 4 hrs | Cavia porcellus | 24 | single protein format | Scientific Literature | ||
7. | ALA3091163 | A | Plasma protein binding in human | Homo sapiens | 51 | cell-free format | Scientific Literature | ||
8. | ALA3091164 | B | Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method | Homo sapiens | 68 | cell-based format | Scientific Literature | ||
9. | ALA3091165 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 56 | assay format | Scientific Literature |