# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3097611 | Functional | Reduction in ascorbic acid-induced mineralization in human Saos2 cells at 10 uM after 7 days by Alizarin Red S staining-based assay relative to control | Homo sapiens | 5 | ALA3091295 | cell-based format | Scientific Literature | |
2. | ALA3097612 | Functional | Reduction in beta-glycerophosphate-induced mineralization in human Saos2 cells at 10 uM after 7 days by Alizarin Red S staining-based assay relative to control | Homo sapiens | 5 | ALA3091295 | cell-based format | Scientific Literature | |
3. | ALA3094823 | ADME | Cytotoxicity against human MG63 cells assessed as cell viability up to 10 uM by MTT assay | Homo sapiens | 5 | ALA3091295 | cell-based format | Scientific Literature | |
4. | ALA3094824 | ADME | Cytotoxicity against human Saos2 cells assessed as cell viability up to 10 uM by MTT assay | Homo sapiens | 5 | ALA3091295 | cell-based format | Scientific Literature | |
5. | ALA3094825 | Binding | Selectivity ratio of IC50 for intestinal alkaline phosphatase (unknown origin) to IC50 for porcine kidney TNAP at pH 7.8 | 5 | ALA3091295 | assay format | Scientific Literature | ||
6. | ALA3094826 | Binding | Selectivity ratio of IC50 for intestinal alkaline phosphatase (unknown origin) to IC50 for porcine kidney TNAP at pH 10.4 | 5 | ALA3091295 | assay format | Scientific Literature | ||
7. | ALA3094827 | Binding | Selectivity ratio of IC50 for placental alkaline phosphatase (unknown origin) to IC50 for porcine kidney TNAP at pH 7.8 | 5 | ALA3091295 | assay format | Scientific Literature | ||
8. | ALA3094828 | Binding | Selectivity ratio of IC50 for placental alkaline phosphatase (unknown origin) to IC50 for porcine kidney TNAP at pH 10.4 | 5 | ALA3091295 | assay format | Scientific Literature | ||
9. | ALA3094829 | Physicochemical | Solubility of the compound in water by UV spectrometric analysis | 4 | ALA3091295 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA3094831 | Binding | Inhibition of intestinal alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 10.4 incubated for 10 mins prior to substrate addition measured after 5 seconds by spectrophotometric analysis | Homo sapiens | 5 | ALA3091295 | single protein format | Scientific Literature | |
11. | ALA3094832 | Binding | Inhibition of intestinal alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 incubated for 10 mins prior to substrate addition measured after 5 seconds by spectrophotometric analysis | Homo sapiens | 5 | ALA3091295 | single protein format | Scientific Literature | |
12. | ALA3095033 | Binding | Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 10.4 incubated for 10 mins prior to substrate addition measured after 5 seconds by spectrophotometric analysis | Homo sapiens | 5 | ALA3091295 | assay format | Scientific Literature | |
13. | ALA3095034 | Binding | Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 incubated for 10 mins prior to substrate addition measured after 5 seconds by spectrophotometric analysis | Homo sapiens | 5 | ALA3091295 | assay format | Scientific Literature | |
14. | ALA3095035 | Binding | Uncompetitive inhibition of porcine kidney TNAP assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 by Michaelis-Menten plot analysis | Sus scrofa | 5 | ALA3091295 | tissue-based format | Scientific Literature | |
15. | ALA3095036 | Binding | Inhibition of porcine kidney TNAP assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 10.4 incubated for 10 mins prior to substrate addition measured after 5 seconds by spectrophotometric analysis | Sus scrofa | 5 | ALA3091295 | assay format | Scientific Literature | |
16. | ALA3095037 | Binding | Inhibition of porcine kidney TNAP assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 incubated for 10 mins prior to substrate addition measured after 5 seconds by spectrophotometric analysis | Sus scrofa | 5 | ALA3091295 | assay format | Scientific Literature |