# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3100725 | F | Antitumor activity against Sprague-Dawley rat mammary tumor cells assessed as increase in apoptotic index at 200 mg/kg, po after 7 days by TUNEL assay relative to control | Rattus norvegicus | 4 | ALA3098106 | organism-based format | Scientific Literature | |
2. | ALA3100726 | F | Antitumor activity against BRDU-labeled Sprague-Dawley rat mammary tumor cells assessed as reduction in proliferation index at 200 mg/kg, po after 7 days relative to control | Rattus norvegicus | 4 | ALA3098106 | organism-based format | Scientific Literature | |
3. | ALA3100728 | T | Toxicity in Sprague-Dawley rat assessed as increase in body weight at 200 mg/kg, po after 7 days relative to control | Rattus norvegicus | 6 | ALA3098106 | organism-based format | Scientific Literature | |
4. | ALA3100729 | F | Inhibition of KLF4-ER-mediated rat RK3E cell transformation after 3 weeks | Rattus norvegicus | 6 | ALA3098106 | cell-based format | Scientific Literature | |
5. | ALA3100730 | T | Toxicity in 50 days old Sprague-Dawley rat assessed as increase in serum triglyceride level at 200 mg/kg, po administered with diet after 7 days relative to control | Rattus norvegicus | 2 | ALA3098106 | organism-based format | Scientific Literature | |
6. | ALA3100731 | B | Agonist activity at human RARalpha expressed in HEK293 cells assessed as transcriptional activation at 10'-6 M after 48 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA3098106 | cell-based format | Scientific Literature | |
7. | ALA3100732 | B | Agonist activity at RXRalpha in rat RK3E cells assessed as transcriptional activation by luciferase reporter gene assay | Rattus norvegicus | 6 | ALA3098106 | cell-based format | Scientific Literature | |
8. | ALA3100733 | B | Binding affinity to human RXRalpha ligand binding domain by fluorescence assay | Homo sapiens | 6 | ALA3098106 | single protein format | Scientific Literature | |
9. | ALA3297474 | B | Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching method | Homo sapiens | 8 | ALA3286246 | single protein format | Scientific Literature | |
10. | ALA3297475 | B | Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay | Homo sapiens | 8 | ALA3286246 | cell-based format | Scientific Literature | |
11. | ALA3297476 | B | Agonist activity at Gal4-fused human RAR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity at 1 uM treated 24 hrs after transfection measured 48 hrs post-transfection by dual luciferase reporter assay | Homo sapiens | 5 | ALA3286246 | cell-based format | Scientific Literature | |
12. | ALA3297477 | B | Agonist activity at human RXR-alpha-ligand binding domain homodimers assessed as coactivator recruitment by measuring GRIP1 binding to receptor by isothermal titration calorimetry | Homo sapiens | 8 | ALA3286246 | single protein format | Scientific Literature | |
13. | ALA3297478 | B | Agonist activity at RXR-alpha in rat R3KE cells infected with oncogene KLF4-ER assessed as inhibition of KLF4-mediated oncogenic transformation | Rattus norvegicus | 8 | ALA3286246 | cell-based format | Scientific Literature | |
14. | ALA3297480 | A | Induction of hyperlipidemia in N-methylnitrosurea-induced mammary cancer Sprague-Dawley rat model assessed as increase in serum triglyceride level at 200 mg/kg administered through diet for 7 days | Rattus norvegicus | 6 | ALA3286246 | organism-based format | Scientific Literature | |
15. | ALA3297482 | F | Anticancer activity against N-methylnitrosurea-induced mammary cancer in Sprague-Dawley rat assessed as decrease in proliferation index at 200 mg/kg administered through diet for 7 days by BrdU incorporation assay | Rattus norvegicus | 6 | ALA3286246 | organism-based format | Scientific Literature | |
16. | ALA3297483 | T | Toxicity in N-methylnitrosurea-induced mammary cancer Sprague-Dawley rat model assessed as body weight at 200 mg/kg administered through diet for 7 days | Rattus norvegicus | 4 | ALA3286246 | organism-based format | Scientific Literature | |
17. | ALA3297484 | T | Toxicity in N-methylnitrosurea-induced mammary cancer Sprague-Dawley rat model assessed as liver weight at 200 mg/kg administered through diet for 7 days | Rattus norvegicus | 4 | ALA3286246 | organism-based format | Scientific Literature | |
18. | ALA3626729 | B | Binding affinity to human RXRalpha LBD after 15 mins by isothermal titration calorimetry assay | Homo sapiens | 5 | ALA3621048 | single protein format | Scientific Literature | |
19. | ALA3626737 | A | Metabolic stability in methylnitrosourea-induced mammary cancer model of Sprague-Dawley rat assessed as compound level in serum at 200 mg/kg treated with diet for 3 months | Rattus norvegicus | 7 | ALA3621048 | organism-based format | Scientific Literature | |
20. | ALA3627126 | F | Anticancer activity in methylnitrosourea-induced mammary cancer model of Sprague-Dawley rat assessed as decrease of tumor size at 200 mg/kg treated with diet for 4 weeks relative to control | Rattus norvegicus | 2 | ALA3621048 | organism-based format | Scientific Literature |