# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3102614 | F | Cell cycle arrest in human Jurkat cells assessed as accumulation at G2/M phase at 10 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
2. | ALA3102615 | F | Cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 10 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
3. | ALA3102616 | A | Selectivity ratio of IC50 for HUVEC to IC50 for human HeLa cells | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
4. | ALA3102617 | A | Selectivity ratio of IC50 for HUVEC to IC50 for human CEM/0 cells | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
5. | ALA3102618 | A | Selectivity ratio of IC50 for HUVEC to IC50 for mouse FM3A/0 cells | 1 | ALA3098049 | cell-based format | Scientific Literature | ||
6. | ALA3102619 | A | Selectivity ratio of IC50 for HUVEC to IC50 for human Molt4/C8 cells | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
7. | ALA3102620 | A | Selectivity ratio of IC50 for HUVEC to IC50 for mouse L1210 cells | 1 | ALA3098049 | cell-based format | Scientific Literature | ||
8. | ALA3102621 | T | Toxicity in Balb/c-nu mouse xenografted with human MNNG-HOS cells assessed as change in body weight at 50 mg/kg, ip administered once every 3 days for 9 days measured after day 18 | Mus musculus | 1 | ALA3098049 | organism-based format | Scientific Literature | |
9. | ALA3102622 | F | Antitumor activity against human MNNG-HOS cells xenografted in Balb/c-nu mouse assessed as tumor growth inhibition at 50 mg/kg, ip measured after 3 days | Homo sapiens | 1 | ALA3098049 | organism-based format | Scientific Literature | |
10. | ALA3102623 | F | Antitumor activity against human MNNG-HOS cells xenografted in Balb/c-nu mouse assessed as reduction in tumor weight at 50 mg/kg, ip administered once every 3 days for 9 days measured after day 18 | Homo sapiens | 2 | ALA3098049 | organism-based format | Scientific Literature | |
11. | ALA3102624 | F | Antitumor activity against human MNNG-HOS cells xenografted in Balb/c-nu mouse assessed as tumor growth inhibition at 50 mg/kg, ip measured on day 18 relative to vehicle-treated control | Homo sapiens | 1 | ALA3098049 | organism-based format | Scientific Literature | |
12. | ALA3102626 | F | Cytotoxicity against human MNNG-HOS cells | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
13. | ALA3102627 | F | Downregulation of Xiap protein expression in human HeLa cells at 10 to 100 nM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
14. | ALA3102628 | F | Downregulation of Bcl-2 protein expression in human HeLa cells at 10 to 100 nM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
15. | ALA3102629 | F | Induction of apoptosis in human HeLa cells assessed as PARP cleavage at 10 nM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
16. | ALA3102630 | F | Induction of apoptosis in human HeLa cells assessed as caspase-9 cleavage at 10 to 100 nM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
17. | ALA3102631 | F | Induction of apoptosis in human HeLa cells assessed as caspase-3 cleavage at 10 to 100 nM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
18. | ALA3102632 | F | Induction of mitochondrial ROS generation in human HeLa cells at 15 to 250 nM by H2-DCFDA staining-based flow cytometric analysis | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
19. | ALA3102633 | F | Induction of mitochondrial membrane depolarization in human HeLa cells at 15 to 250 nM by JC-1 staining-based fluorescence assay | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature | |
20. | ALA3102634 | F | Induction of mitochondrial ROS generation in human HeLa cells after 24 to 48 hrs by H2-DCFDA staining-based flow cytometric analysis | Homo sapiens | 1 | ALA3098049 | cell-based format | Scientific Literature |