# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3101099 | Binding | Activation of HRI in human CRL-2813-pBISA-DL(ATF-4) reporter cells assessed as concentration required to obtain F-luciferase expression/R-luciferase expression ratio 3 | Homo sapiens | 30 | ALA3098030 | assay format | Scientific Literature | |
2. | ALA3101103 | Functional | Antiproliferative activity against human MCF7 cells after 5 days by SRB assay in presence of HRI-targeting siRNA | Homo sapiens | 4 | ALA3098030 | cell-based format | Scientific Literature | |
3. | ALA3101104 | Functional | Antiproliferative activity against human MCF7 cells after 5 days by SRB assay in presence of non-targeting siRNA | Homo sapiens | 4 | ALA3098030 | cell-based format | Scientific Literature | |
4. | ALA3101105 | Functional | Antiproliferative activity against human CRL2813 cells after 5 days by SRB assay in presence of HRI-targeting siRNA | Homo sapiens | 4 | ALA3098030 | cell-based format | Scientific Literature | |
5. | ALA3101106 | Functional | Antiproliferative activity against human CRL2813 cells after 5 days by SRB assay in presence of non-targeting siRNA | Homo sapiens | 4 | ALA3098030 | cell-based format | Scientific Literature | |
6. | ALA3101107 | Binding | Activation of HRI in human CRL-2813-pBISA-DL(ATF-4) reporter cells assessed as eIF2alpha phosphorylation after 10 hrs by dual-luciferase reporter gene assay in presence of siRNA relative to control | Homo sapiens | 4 | ALA3098030 | assay format | Scientific Literature | |
7. | ALA3101108 | Binding | Activation of HRI in human CRL2813 cells assessed as reduction in cyclin D1 mRNA expression at 7.5 to 15 uM after 6 hrs by RT-PCR analysis | Homo sapiens | 6 | ALA3098030 | cell-based format | Scientific Literature | |
8. | ALA3101109 | Binding | Activation of HRI in human CRL2813 cells assessed as increase in CHOP mRNA expression at 7.5 to 15 uM after 6 hrs by RT-PCR analysis | Homo sapiens | 6 | ALA3098030 | cell-based format | Scientific Literature | |
9. | ALA3101110 | Binding | Activation of HRI in human CRL2813 cells assessed as reduction in cyclin D1 protein expression at 10 uM after 6 hrs by Western blotting analysis | Homo sapiens | 6 | ALA3098030 | cell-based format | Scientific Literature | |
10. | ALA3101111 | Binding | Activation of HRI in human CRL2813 cells assessed as increase in CHOP protein expression at 10 uM after 6 hrs by Western blotting analysis | Homo sapiens | 6 | ALA3098030 | cell-based format | Scientific Literature | |
11. | ALA3101112 | Binding | Activation of HRI in human CRL2813 cells assessed as eIF2alpha phosphorylation after 6 hrs by Western blotting analysis | Homo sapiens | 6 | ALA3098030 | cell-based format | Scientific Literature | |
12. | ALA3101113 | Functional | Cytotoxicity against human CRL2813 cells after 5 days by SRB assay | Homo sapiens | 48 | ALA3098030 | cell-based format | Scientific Literature | |
13. | ALA3101114 | Binding | Activation of HRI in human CRL-2813-pBISA-DL(ATF-4) reporter cells assessed as reduction of ternary complex at 30 uM by dual-luciferase reporter gene assay relative to control | Homo sapiens | 48 | ALA3098030 | assay format | Scientific Literature | |
14. | ALA3101115 | Functional | Ratio of IC50 for human CRL2813 cells after 5 days by SRB assay in presence of HRI-targeting siRNA to IC50 for human CRL2813 cells after 5 days by SRB assay in presence of non-targeting siRNA | Homo sapiens | 4 | ALA3098030 | cell-based format | Scientific Literature |