| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3101099 | B | Activation of HRI in human CRL-2813-pBISA-DL(ATF-4) reporter cells assessed as concentration required to obtain F-luciferase expression/R-luciferase expression ratio 3 | Homo sapiens | 30 | assay format | Scientific Literature | ||
| 2. | ALA3101103 | F | Antiproliferative activity against human MCF7 cells after 5 days by SRB assay in presence of HRI-targeting siRNA | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA3101104 | F | Antiproliferative activity against human MCF7 cells after 5 days by SRB assay in presence of non-targeting siRNA | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA3101105 | F | Antiproliferative activity against human CRL2813 cells after 5 days by SRB assay in presence of HRI-targeting siRNA | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA3101106 | F | Antiproliferative activity against human CRL2813 cells after 5 days by SRB assay in presence of non-targeting siRNA | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA3101107 | B | Activation of HRI in human CRL-2813-pBISA-DL(ATF-4) reporter cells assessed as eIF2alpha phosphorylation after 10 hrs by dual-luciferase reporter gene assay in presence of siRNA relative to control | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 7. | ALA3101108 | B | Activation of HRI in human CRL2813 cells assessed as reduction in cyclin D1 mRNA expression at 7.5 to 15 uM after 6 hrs by RT-PCR analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 8. | ALA3101109 | B | Activation of HRI in human CRL2813 cells assessed as increase in CHOP mRNA expression at 7.5 to 15 uM after 6 hrs by RT-PCR analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 9. | ALA3101110 | B | Activation of HRI in human CRL2813 cells assessed as reduction in cyclin D1 protein expression at 10 uM after 6 hrs by Western blotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA3101111 | B | Activation of HRI in human CRL2813 cells assessed as increase in CHOP protein expression at 10 uM after 6 hrs by Western blotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 11. | ALA3101112 | B | Activation of HRI in human CRL2813 cells assessed as eIF2alpha phosphorylation after 6 hrs by Western blotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 12. | ALA3101113 | F | Cytotoxicity against human CRL2813 cells after 5 days by SRB assay | Homo sapiens | 48 | cell-based format | Scientific Literature | ||
| 13. | ALA3101114 | B | Activation of HRI in human CRL-2813-pBISA-DL(ATF-4) reporter cells assessed as reduction of ternary complex at 30 uM by dual-luciferase reporter gene assay relative to control | Homo sapiens | 48 | assay format | Scientific Literature | ||
| 14. | ALA3101115 | F | Ratio of IC50 for human CRL2813 cells after 5 days by SRB assay in presence of HRI-targeting siRNA to IC50 for human CRL2813 cells after 5 days by SRB assay in presence of non-targeting siRNA | Homo sapiens | 4 | cell-based format | Scientific Literature |
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