| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3101097 | F | Antiproliferative activity against human CRL2813 cells after 3 days by SRB assay in presence of HRI-targeting siRNA | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA3101098 | F | Antiproliferative activity against human CRL2813 cells after 3 days by SRB assay in presence of non-targeting siRNA | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA3101099 | B | Activation of HRI in human CRL-2813-pBISA-DL(ATF-4) reporter cells assessed as concentration required to obtain F-luciferase expression/R-luciferase expression ratio 3 | Homo sapiens | 30 | assay format | Scientific Literature | ||
| 4. | ALA3101100 | A | Selectivity ratio of IC50 for mouse NIH/3T3 cells to IC50 for human CRL2813 cells | 4 | cell-based format | Scientific Literature | |||
| 5. | ALA3101101 | A | Cytotoxicity against mouse NIH/3T3 cells after 5 days by SRB assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA3101113 | F | Cytotoxicity against human CRL2813 cells after 5 days by SRB assay | Homo sapiens | 48 | cell-based format | Scientific Literature | ||
| 7. | ALA3101114 | B | Activation of HRI in human CRL-2813-pBISA-DL(ATF-4) reporter cells assessed as reduction of ternary complex at 30 uM by dual-luciferase reporter gene assay relative to control | Homo sapiens | 48 | assay format | Scientific Literature | ||
| 8. | ALA4012848 | B | Activation of HRI in mouse KLN cells transfected with 5'UTR of ATF-4 mRNA fused firefly luciferase mRNA and 5'UTR lacking uORF fused renila luciferase mRNA assessed as increase in eIF2alpha phosphorylation by measuring ratio of firefly luciferase to renila luciferase at 1.25 uM after 16 hrs | Mus musculus | 24 | cell-based format | Scientific Literature | ||
| 9. | ALA4012849 | B | Activation of HRI in mouse KLN cells transfected with 5'UTR of ATF-4 mRNA fused firefly luciferase mRNA and 5'UTR lacking uORF fused renila luciferase mRNA assessed as increase in eIF2alpha phosphorylation by measuring ratio of firefly luciferase to renila luciferase at 5 uM after 16 hrs | Mus musculus | 24 | cell-based format | Scientific Literature | ||
| 10. | ALA4012850 | F | Antiproliferative activity against human CRL2813 cells after 5 days by sulforhodamine B assay | Homo sapiens | 24 | cell-based format | Scientific Literature |
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