| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3107136 | B | Inhibition of human HPGD in human ME180 cells assessed as downregulation of TNFalpha-induced NF-kappaB expression at 647 pM to 38.2 uM incubated for 15 mins prior to TNFalpha addition measured after 4 to 24 hrs by beta-lactamase reporter gene assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA3107137 | F | Induction of PGE2 production in human LNCAP cells at 41.9 nM to 100 uM after 16 hrs by HTRF assay relative to control | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 3. | ALA3107138 | F | Induction of PGE2 production in human LNCAP cells assessed as half-maximal activation concentration after 16 hrs by HTRF assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 4. | ALA3107139 | F | Induction of PGE2 production in human A549 cells at 775 pM to 45.8 uM after 4 to 20 hrs by HTRF assay relative to control | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 5. | ALA3107140 | F | Induction of PGE2 production in human A549 cells assessed as concentration required for half-maximal activation after 4 to 20 hrs by HTRF assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 6. | ALA3107141 | B | Selectivity ratio of IC50 for ALDH1A1 (unknown origin) to IC50 for human HPGD | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 7. | ALA3107142 | B | Inhibition of ALDH1A1 (unknown origin) using NAD+/propionaldehyde as substrate after 15 mins by UV-fluorescence assay | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 8. | ALA3107143 | B | Inhibition of HSD17beta4 (unknown origin) using NAD+/estradiol as substrate at 324 pM to 57.2 uM after 15 mins by UV-fluorescence assay | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 9. | ALA3107144 | B | Inhibition of LDHB (unknown origin) using sodium pyruvate as substrate at 0.46 to 57.5 uM after 15 mins by fluorescence assay | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 10. | ALA3107145 | B | Inhibition of LDHA (unknown origin) using sodium pyruvate as substrate at 0.46 to 57.5 uM after 15 mins by fluorescence assay | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 11. | ALA3107146 | B | Inhibition of rabbit muscle GAPDH using glyceraldehyde-3-phosphate as substrate at 324 pM to 57.2 uM by fluorescence assay | Oryctolagus cuniculus | 9 | single protein format | Scientific Literature | ||
| 12. | ALA3107147 | P | Kinetic solubility of the compound in PBS buffer at pH 7.4 | 11 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA3107148 | A | Half life in rat liver microsomes in presence of NADPH | Rattus norvegicus | 11 | assay format | Scientific Literature | ||
| 14. | ALA3107149 | A | Passive permeability of the compound at pH 7.4 by PAMPA | 11 | assay format | Scientific Literature | |||
| 15. | ALA3107150 | B | Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay | Homo sapiens | 55 | single protein format | Scientific Literature | ||
| 16. | ALA3562125 | F | PubChem BioAssay. Extended Characterization of HPGD Inhibitors: Counterscreen Against ALDH1A1. (Class of assay: confirmatory) | Homo sapiens | 218 | assay format | PubChem BioAssays | ||
| 17. | ALA3562140 | F | PubChem BioAssay. Extended Characterization of HPGD Inhibitors: Activity in Primary Assay (HPGD). (Class of assay: confirmatory) | 82 | assay format | PubChem BioAssays |
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