| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3108472 | B | Negative allosteric modulation of human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in ATP-induced cytosolic calcium influx at 3 to 30 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA3108473 | B | Selectivity ratio of IC50 for mouse P2X4 receptor to IC50 for human P2X4 receptor | 5 | assay format | Scientific Literature | |||
| 3. | ALA3108475 | B | Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA3108476 | B | Selectivity ratio of IC50 for rat P2X4 receptor to IC50 for human P2X4 receptor | 3 | assay format | Scientific Literature | |||
| 5. | ALA3108477 | B | Antagonist activity at human P2X3 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA3108478 | B | Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx at 100 uM preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 7. | ALA3108479 | B | Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 8. | ALA3108480 | B | Antagonist activity at human P2X1 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 9. | ALA3108481 | B | Antagonist activity at rat P2X4 receptor assessed as inhibition of ATP-induced calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | Rattus norvegicus | 6 | single protein format | Scientific Literature | ||
| 10. | ALA3106338 | B | Antagonist activity at mouse P2X4 receptor assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | Mus musculus | 6 | single protein format | Scientific Literature | ||
| 11. | ALA3106504 | B | Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx at 10 uM preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 12. | ALA3106505 | B | Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | Homo sapiens | 54 | cell-based format | Scientific Literature |
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