Cardiotoxicity in telemetered spontaneously hypertensive rat assessed as heart rate measured as area between curve at 100 mg/kg, po administered at wake phase
Cardiotoxicity in telemetered spontaneously hypertensive rat assessed as heart rate measured as area between curve at 30 mg/kg, po administered at wake phase
Cardiotoxicity in telemetered spontaneously hypertensive rat assessed as heart rate measured as area between curve at 10 mg/kg, po administered at wake phase
Cardiotoxicity in telemetered spontaneously hypertensive rat assessed as heart rate at 100 mg/kg, po administered at wake phase measured up to 24 hrs relative to control
Cardiotoxicity in telemetered spontaneously hypertensive rat assessed as heart rate at 30 mg/kg, po administered at wake phase measured up to 24 hrs relative to control
Cardiotoxicity in telemetered po dosed spontaneously hypertensive rat assessed as change in heart rate administered at wake phase measured after 8 to 10 hrs
Cardiotoxicity in telemetered spontaneously hypertensive rat assessed as change in heart rate at 10 to 100 mg/kg, po administered at wake phase measured for 8 hrs
Cardiotoxicity in telemetered spontaneously hypertensive rat assessed as increase in mean arterial pressure at 3 to 100 mg/kg, po administered at wake phase measured up to 24 hrs
Agonist activity at rat S1P3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount scintillation counting analysis
Agonist activity at rat S1P1 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount scintillation counting analysis
Agonist activity at human recombinant S1P5 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount scintillation counting analysis
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount scintillation counting analysis
Agonist activity at human recombinant S1P2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount scintillation counting analysis