# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3106375 | B | Binding affinity to Escherichia coli supercoiled pUC19 DNA assessed as intercalation at 0.2 to 5 uM by agarose gel electrophoresis in presence of human DNA topoisomerase 1 | Escherichia coli | 3 | nucleic acid format | Scientific Literature | ||
2. | ALA3106376 | B | Inhibition of DNA topoisomerase 2 (unknown origin)-mediated DNA cleavage assessed as linear band at 50 uM by agarose gel electrophoresis | Homo sapiens | 15 | single protein format | Scientific Literature | ||
3. | ALA3106377 | B | Inhibition of human topoisomerase 1-mediated DNA cleavage assessed as accumulation of nicked DNA at 1 to 50 uM by agarose gel electrophoresis | Homo sapiens | 11 | single protein format | Scientific Literature | ||
4. | ALA3106954 | B | Binding affinity to DNA (unknown origin) assessed as inhibition of DNase1-mediated cleavage at 2 to 5 uM by DNase1 footprinting assay | Not specified | 3 | assay format | Scientific Literature | ||
5. | ALA3106955 | B | Binding affinity to calf thymus DNA at 50 uM by circular dichroism spectra analysis | Bos taurus | 6 | nucleic acid format | Scientific Literature | ||
6. | ALA3106958 | B | Binding affinity to calf thymus DNA assessed as hypochromic effect at 20 uM by UV-Visible spectroscopy relative to control | Bos taurus | 6 | nucleic acid format | Scientific Literature | ||
7. | ALA3106959 | B | Binding affinity to calf thymus DNA assessed as change in melting temperature at 1 drug/DNA ratio by spectrophotometry | Bos taurus | 13 | nucleic acid format | Scientific Literature | ||
8. | ALA3106960 | B | Binding affinity to calf thymus DNA assessed as change in melting temperature at 0.5 drug/DNA ratio by spectrophotometry | Bos taurus | 14 | nucleic acid format | Scientific Literature | ||
9. | ALA3106961 | F | Cytotoxicity against human H460 cells after 72 hrs by MTT assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
10. | ALA3106962 | B | Binding affinity to calf thymus DNA assessed as change in melting temperature at 0.25 drug/DNA ratio by spectrophotometry | Bos taurus | 10 | nucleic acid format | Scientific Literature | ||
11. | ALA3106963 | F | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
12. | ALA3106964 | F | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | Homo sapiens | 19 | cell-based format | Scientific Literature |