# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3110645 | ADME | Metabolic stability in human plasma assessed as compound remaining after 2 hrs | Homo sapiens | 3 | ALA3108713 | cell-free format | Scientific Literature | |
2. | ALA3110646 | ADME | Metabolic stability in mouse plasma assessed as compound remaining after 2 hrs | Mus musculus | 3 | ALA3108713 | cell-free format | Scientific Literature | |
3. | ALA3110647 | ADME | Half life in human liver microsomes | Homo sapiens | 3 | ALA3108713 | assay format | Scientific Literature | |
4. | ALA3110648 | ADME | Half life in rat liver microsomes | Rattus norvegicus | 3 | ALA3108713 | assay format | Scientific Literature | |
5. | ALA3110649 | ADME | Half life in mouse liver microsomes | Mus musculus | 3 | ALA3108713 | microsome format | Scientific Literature | |
6. | ALA3110650 | Physicochemical | Aqueous kinetic solubility of the compound | 3 | ALA3108713 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA3110651 | ADME | Cytotoxicity against human MRC5 cells assessed as intracellular ATP content after 72 hrs by Cell titer-Glo luminiscent assay | Homo sapiens | 3 | ALA3108713 | cell-based format | Scientific Literature | |
8. | ALA3110652 | Functional | Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 assessed as cell viability at 1.3 to 33.3 ug/ml after 72 hrs by alamar blue assay | Trypanosoma brucei brucei | 1 | ALA3108713 | organism-based format | Scientific Literature | |
9. | ALA3110575 | Binding | Inhibition of recombinant rabbit muscle PFK expressed in PFK-deficient Escherichia coli DF1020DE3 using ATP/fructose 6 phosphate as substrate at 1 uM | Oryctolagus cuniculus | 1 | ALA3108713 | tissue-based format | Scientific Literature | |
10. | ALA3110576 | Binding | Mixed type inhibition Trypanosoma brucei PFK using ATP as substrate by Line-weaver Burk plot analysis | Trypanosoma brucei | 1 | ALA3108713 | single protein format | Scientific Literature | |
11. | ALA3110577 | Binding | Competitive inhibition Trypanosoma brucei PFK using fructose-6-phosphate as substrate by Line-weaver Burk plot analysis | Trypanosoma brucei | 1 | ALA3108713 | single protein format | Scientific Literature | |
12. | ALA3110578 | Binding | Inhibition of Trypanosoma cruzi PFK at 57 uM | Trypanosoma cruzi | 37 | ALA3108713 | single protein format | Scientific Literature | |
13. | ALA3110579 | Binding | Inhibition of Trypanosoma cruzi PFK | Trypanosoma cruzi | 42 | ALA3108713 | single protein format | Scientific Literature | |
14. | ALA3110580 | Binding | Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate at 57 uM by luciferase based luminescence assay | Trypanosoma brucei | 37 | ALA3108713 | single protein format | Scientific Literature | |
15. | ALA3110581 | Binding | Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay | Trypanosoma brucei | 44 | ALA3108713 | single protein format | Scientific Literature | |
16. | ALA4480800 | Binding | Inhibition of Trypanosoma cruzi apoenzyme form of PFK | Trypanosoma cruzi | 46 | ALA4480385 | assay format | Scientific Literature | |
17. | ALA4480801 | Binding | Inhibition of Trypanosoma cruzi holoenzyme form of PFK | Trypanosoma cruzi | 32 | ALA4480385 | assay format | Scientific Literature |