# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3110584 | B | Inhibition of bovine ARTD1 assessed as incorporation of [adenine-2,8-3H]NAD after 1 hr by liquid scintillation spectrometric analysis | Bos taurus | 1 | ALA3108736 | single protein format | Scientific Literature | |
2. | ALA3110587 | B | Inhibition of human N-terminal 6xhis-tagged ARTD6 (873 to 1161) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ as substrate by fluorescence assay | Homo sapiens | 5 | ALA3108736 | cell-based format | Scientific Literature | |
3. | ALA3110588 | B | Inhibition of human 6xhis-tagged ARTD5 (1030 to 1317) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ as substrate by fluorescence assay | Homo sapiens | 6 | ALA3108736 | cell-based format | Scientific Literature | |
4. | ALA3225199 | B | Inhibition of human recombinant PARP1 by fluorescence based multiwell assay | Homo sapiens | 3 | ALA3217609 | single protein format | Scientific Literature | |
5. | ALA3225200 | B | Inhibition of mouse recombinant PARP2 assessed as radioactivity incorporated from [adenine-2,8-3H]NAD into proteins by liquid scintillation spectrometry | Mus musculus | 3 | ALA3217609 | single protein format | Scientific Literature | |
6. | ALA3225201 | B | Inhibition of tankyrase-1 function in human HeLa cells | Homo sapiens | 3 | ALA3217609 | cell-based format | Scientific Literature | |
7. | ALA3225203 | P | Kinetic aqueous solubility of the compound at pH 7.4 at 23 degC | 2 | ALA3217609 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4043750 | B | Binding affinity to G-quadruplex DNA in human BJeH-LT cells at 1 uM after 24 hrs by hoechst staining-based immunofluorescence analysis | Homo sapiens | 11 | ALA4043091 | cell-based format | Scientific Literature | |
9. | ALA4043751 | F | Induction of DNA damage in human BJeH-LT cells assessed as increase in gamma-H2AX foci formation at 1 uM after 24 hrs by hoechst staining-based immunofluorescence analysis | Homo sapiens | 6 | ALA4043091 | cell-based format | Scientific Literature | |
10. | ALA4043756 | F | Antiproliferative activity against human DLD1 cells harboring BRCA2 up to 2 uM after 6 days by MTT assay | Homo sapiens | 2 | ALA4043091 | cell-based format | Scientific Literature | |
11. | ALA4043757 | F | Antiproliferative activity against human DLD1 cells deficient BRCA2 up to 2 uM after 6 days by MTT assay | Homo sapiens | 2 | ALA4043091 | cell-based format | Scientific Literature | |
12. | ALA4495582 | F | SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate | Severe acute respiratory syndrome coronavirus 2 | 7,212 | ALA4495564 | assay format | SARS-CoV-2 Screening Data 2020-21 | |
13. | ALA4513082 | F | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 7,212 | ALA4495565 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
14. | ALA5057858 | B | Inhibition of PARP14 (unknown origin) using NAD+ as substrate incubated for 18 hrs by fluorescence based assay | Homo sapiens | 8 | ALA5055677 | single protein format | Scientific Literature | |
15. | ALA5057862 | B | Inhibition of TNKS2 (unknown origin) | Homo sapiens | 1 | ALA5055677 | single protein format | Scientific Literature | |
16. | ALA5057863 | B | Inhibition of C-terminal His6-tagged/N-terminal PARP10 (809 to 1017 residues) (unknown origin) expressed in Escherichia coli Rosetta2 (DE3) | Homo sapiens | 1 | ALA5055677 | assay format | Scientific Literature | |
17. | ALA5057864 | B | Inhibition of TEV cleavage site fused N-terminal 6His-tagged PARP15 (482 to 678 residues) (unknown origin) expressed in Escherichia coli Rosetta2 (DE3) | Homo sapiens | 1 | ALA5055677 | assay format | Scientific Literature |