# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3110843 | F | Anesthetic effect in mouse assessed as recovery of righting reflex at 1 to 8 mg/kg, iv | Mus musculus | 3 | ALA3108741 | organism-based format | Scientific Literature | |
2. | ALA3110844 | F | Anesthetic effect in mouse assessed as recovery of righting reflex at 8 to 16 mg/kg, iv | Mus musculus | 3 | ALA3108741 | organism-based format | Scientific Literature | |
3. | ALA3110845 | F | Anesthetic effect in mouse assessed as onset of loss of righting reflex at 1 to 8 mg/kg, iv | Mus musculus | 3 | ALA3108741 | organism-based format | Scientific Literature | |
4. | ALA3110846 | F | Anesthetic effect in mouse assessed as onset of loss of righting reflex at 8 to 16 mg/kg, iv | Mus musculus | 3 | ALA3108741 | organism-based format | Scientific Literature | |
5. | ALA3110847 | P | Lipophilicity, log P of the compound | 5 | ALA3108741 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA3110848 | F | Anesthetic effect in mouse assessed as duration of loss of righting reflex at 4 mg/kg, iv | Mus musculus | 1 | ALA3108741 | organism-based format | Scientific Literature | |
7. | ALA3110849 | F | Anesthetic effect in mouse assessed as duration of loss of righting reflex at 2 mg/kg, iv | Mus musculus | 1 | ALA3108741 | organism-based format | Scientific Literature | |
8. | ALA3110850 | F | Anesthetic effect in mouse assessed as duration of loss of righting reflex at 1 mg/kg, iv | Mus musculus | 1 | ALA3108741 | organism-based format | Scientific Literature | |
9. | ALA3110852 | F | Anesthetic effect in mouse assessed as duration of loss of righting reflex at 8 mg/kg, iv | Mus musculus | 2 | ALA3108741 | organism-based format | Scientific Literature | |
10. | ALA3110855 | F | Anesthetic effect on prelimb-bud stage Xenopus laevis tadpole assessed as loss of swimming reflex after 3 hrs | Xenopus laevis | 11 | ALA3108741 | organism-based format | Scientific Literature | |
11. | ALA3110856 | F | Anesthetic effect on prelimb-bud stage Xenopus laevis tadpole assessed as loss of righting reflex after 3 hrs | Xenopus laevis | 12 | ALA3108741 | organism-based format | Scientific Literature | |
12. | ALA3110857 | B | Positive allosteric modulation of wild type rat alpha1beta2gamma2L GABAA receptor expressed in HEK293 cells assessed as longest-lived intracluster closed time at 20 uM by by two-electrode voltage clamp technique relative to control | Rattus norvegicus | 5 | ALA3108741 | cell-based format | Scientific Literature | |
13. | ALA3110858 | B | Positive allosteric modulation of wild type rat alpha1beta2gamma2L GABAA receptor expressed in HEK293 cells assessed as longest-lived intracluster open time at 20 uM by by two-electrode voltage clamp technique relative to control | Rattus norvegicus | 5 | ALA3108741 | cell-based format | Scientific Literature | |
14. | ALA3110859 | B | Positive allosteric modulation of wild type rat alpha1beta2gamma2L GABAA receptor expressed in HEK293 cells assessed as OT long at 20 uM by by two-electrode voltage clamp technique | Rattus norvegicus | 5 | ALA3108741 | cell-based format | Scientific Literature | |
15. | ALA3110860 | B | Positive allosteric modulation of rat alpha1W245Lbeta2gamma2L GABAA receptor mutant expressed in HEK293 cells assessed as potentiation of GABA-induced chloride current elicitation at 20 uM by two-electrode voltage clamp technique relative to control | Rattus norvegicus | 2 | ALA3108741 | cell-based format | Scientific Literature | |
16. | ALA3110861 | B | Positive allosteric modulation of rat alpha1S240Lbeta2gamma2L GABAA receptor mutant expressed in HEK293 cells assessed as potentiation of GABA-induced chloride current elicitation at 20 uM by two-electrode voltage clamp technique relative to control | Rattus norvegicus | 2 | ALA3108741 | cell-based format | Scientific Literature | |
17. | ALA3110862 | B | Positive allosteric modulation of rat alpha1Q241Lbeta2gamma2L GABAA receptor mutant expressed in HEK293 cells assessed as potentiation of GABA-induced chloride current elicitation at 20 uM by two-electrode voltage clamp technique relative to control | Rattus norvegicus | 2 | ALA3108741 | cell-based format | Scientific Literature | |
18. | ALA3110863 | B | Positive allosteric modulation of wild type rat alpha1beta2gamma2L GABAA receptor expressed in HEK293 cells assessed as potentiation of GABA-induced chloride current elicitation at 20 uM by two-electrode voltage clamp technique relative to control | Rattus norvegicus | 2 | ALA3108741 | cell-based format | Scientific Literature | |
19. | ALA3110864 | B | Positive allosteric modulation of rat alpha1beta2gamma2L GABAA receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current elicitation by two-electrode voltage clamp technique relative to control | Rattus norvegicus | 14 | ALA3108741 | cell-based format | Scientific Literature | |
20. | ALA3110865 | B | Positive allosteric modulation of rat alpha1beta2gamma2L GABAA receptor expressed in Xenopus laevis oocytes assessed as chloride current elicitation at 10 uM by two-electrode voltage clamp technique relative to GABA | Rattus norvegicus | 14 | ALA3108741 | cell-based format | Scientific Literature |