| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3110427 | F | Antimalarial activity against Plasmodium chabaudi ASS infected in NIH mouse assessed as inhibition of parasitemia at 150 to 300 mg/kg, po qd for 4 days | Plasmodium chabaudi | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA3110429 | T | Toxicity in Plasmodium chabaudi ASS infected NIH mouse assessed as survival at 10 to 300 mg/kg, po qd for 4 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA3110430 | A | Plasma concentration in Plasmodium chabaudi ASS infected NIH mouse at 100 mg/kg, po qd measured 6 hrs after post last dose on day 3 | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 4. | ALA3110431 | A | Plasma concentration in Plasmodium chabaudi ASS infected NIH mouse at 100 mg/kg, po qd measured 24 hrs after post last dose on day 3 | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 5. | ALA3110432 | A | Plasma concentration in Plasmodium chabaudi ASS infected NIH mouse at 100 mg/kg, po qd measured 1 hr after post last dose on day 3 | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA3110434 | F | Antimalarial activity against Plasmodium chabaudi ASS infected in NIH mouse assessed as inhibition of parasitemia at 100 mg/kg, po qd for 4 days | Plasmodium chabaudi | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA3110805 | A | Half life in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA3110806 | A | Metabolic stability in human liver microsomes at 1 uM after 5 to 30 mins | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA3110807 | A | Metabolic stability in rat liver microsomes at 1 uM after 5 to 30 mins | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 10. | ALA3110808 | A | Metabolic stability in mouse liver microsomes at 1 uM after 5 to 30 mins | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 11. | ALA3110809 | A | Inhibition of human recombinant CYP3A4 after 30 mins | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA3110810 | A | Inhibition of human recombinant CYP2C19 after 30 mins | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA3110811 | A | Inhibition of human recombinant CYP2D6 after 30 mins | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 14. | ALA3110812 | A | Inhibition of human recombinant CYP2C9 after 30 mins | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 15. | ALA3110813 | A | Inhibition of human recombinant CYP1A2 after 30 mins | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 16. | ALA3110814 | A | Cytotoxicity against human HepG2 cells after 72 hrs | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA3110815 | F | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 48 hrs by SYBR Green I-based fluorescence method | Plasmodium falciparum | 4 | organism-based format | Scientific Literature | ||
| 18. | ALA3110816 | F | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum Dd2 infected in RBV after 48 hrs by SYBR Green I-based fluorescence method | Plasmodium falciparum | 4 | assay format | Scientific Literature | ||
| 19. | ALA3110817 | B | Selectivity ratio of IC50 for human cathepsin E to IC50 for Plasmodium falciparum plasmepsin-2 | 2 | assay format | Scientific Literature | |||
| 20. | ALA3110818 | B | Selectivity ratio of IC50 for human cathepsin D to IC50 for Plasmodium falciparum plasmepsin-2 | 2 | assay format | Scientific Literature |
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