# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA681824 | Functional | Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL | Homo sapiens | 61 | ALA1148380 | cell-based format | Scientific Literature | |
2. | ALA681826 | Functional | pIC50 value for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL | Homo sapiens | 61 | ALA1148380 | cell-based format | Scientific Literature | |
3. | ALA902036 | Functional | Bone mineral affinity on hydroxyaptite assessed as retention time by chromatography | 10 | ALA1138296 | assay format | Scientific Literature | ||
4. | ALA902037 | Binding | Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3) | Homo sapiens | 9 | ALA1138296 | assay format | Scientific Literature | |
5. | ALA902038 | ADME | Reduction of viability of mouse J744 cells after 48 hrs | Mus musculus | 10 | ALA1138296 | cell-based format | Scientific Literature | |
6. | ALA902039 | Binding | Inhibition of RGGT mediated Rap1A prenylation in J744 cells | Mus musculus | 5 | ALA1138296 | cell-based format | Scientific Literature | |
7. | ALA3369319 | Binding | Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by liquid scintillation counting analysis | Homo sapiens | 14 | ALA3297739 | single protein format | Scientific Literature | |
8. | ALA3369326 | Binding | Inhibition of FPPS in human SH-SY5Y cells assessed as blocking of tau metabolism by measuring ratio of tau phosphorylation to total tau level at 100 nM after 24 hrs by ELISA (Rvb = 0.012 no-unit) | Homo sapiens | 14 | ALA3297739 | cell-based format | Scientific Literature | |
9. | ALA3369327 | ADME | Cytotoxicity against human SH-SY5Y cells assessed as LDH release after 48 hrs (Rvb = 0%) | Homo sapiens | 14 | ALA3297739 | cell-based format | Scientific Literature | |
10. | ALA786021 | Functional | Bone resorption activity in rats. | Rattus norvegicus | 35 | ALA1135492 | organism-based format | Scientific Literature | |
11. | ALA924793 | Binding | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | Homo sapiens | 27 | ALA1142396 | assay format | Scientific Literature | |
12. | ALA924794 | Binding | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | Homo sapiens | 27 | ALA1142396 | assay format | Scientific Literature | |
13. | ALA924795 | Functional | Inhibition of bone resorption in rat assessed as phosphate | Rattus norvegicus | 23 | ALA1142396 | organism-based format | Scientific Literature | |
14. | ALA1028089 | Binding | Inhibition of human recombinant geranylgeranyl diphosphate synthase | Homo sapiens | 59 | ALA1140129 | single protein format | Scientific Literature | |
15. | ALA3065755 | Binding | Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrate | Aquifex aeolicus | 21 | ALA3044605 | assay format | Scientific Literature |