| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3110473 | B | Inhibition of TLR4/IL-1R in BALB/c mouse BMDM assessed as downregulation of LPS-stimulated MyD88 expression at 5 ug/mL preincubated for 2 hrs followed by LPS challenge measured after 18 hrs by flow cytometric analysis (Rvb = 127%) | Mus musculus | 1 | ALA3108700 | assay format | Scientific Literature | |
| 2. | ALA3110474 | B | Inhibition of TLR4/IL-1R in BALB/c mouse BMDM assessed as downregulation of LPS-stimulated MyD88 protein expression at 5 ug/mL after 20 hrs by Western blotting analysis relative to control | Mus musculus | 1 | ALA3108700 | assay format | Scientific Literature | |
| 3. | ALA3110475 | B | Inhibition of TLR4/IL-1R in BALB/c mouse BMDM assessed as downregulation of LPS-stimulated MyD88 protein expression at 1 ug/mL after 20 hrs by Western blotting analysis relative to control | Mus musculus | 1 | ALA3108700 | assay format | Scientific Literature | |
| 4. | ALA3110476 | B | Inhibition of TLR4 in ovalbumin pulsed C57BL/6 mouse BMDC co-cultured with OT-2 CD4+ T cells assessed as reduction of LPS-induced IL-17 production at 5 ug/mL after 3 days by ELISA | Mus musculus | 1 | ALA3108700 | cell-based format | Scientific Literature | |
| 5. | ALA3110477 | B | Inhibition of TLR4 in ovalbumin pulsed BALB/c mouse BMDC co-cultured with DO-11.10 CD4+ T cells assessed as reduction of LPS-induced IL-17 production at 5 ug/mL after 3 days by ELISA | Mus musculus | 1 | ALA3108700 | cell-based format | Scientific Literature | |
| 6. | ALA3110478 | A | Cytotoxicity against mouse BMDC assessed as reduction in cell viability | Mus musculus | 1 | ALA3108700 | assay format | Scientific Literature | |
| 7. | ALA3110479 | F | Antiinflammatory activity in mouse BMDC assessed as downregulation of TLR4 expression | Mus musculus | 1 | ALA3108700 | assay format | Scientific Literature | |
| 8. | ALA3110480 | B | Inhibition of TLR4 in C57BL/6 mouse BMDC assessed as reduction of LPS-induced IL-23 production at 5 ug/mL preincubated for 2 hrs prior to LPS challenge measured after 24 hrs by ELISA | Mus musculus | 1 | ALA3108700 | single protein format | Scientific Literature | |
| 9. | ALA3110481 | B | Inhibition of TLR4 in C57BL/6 mouse BMDC assessed as reduction of LPS-induced IL-6 production at 5 ug/mL preincubated for 2 hrs prior to LPS challenge measured after 24 hrs by ELISA | Mus musculus | 1 | ALA3108700 | single protein format | Scientific Literature | |
| 10. | ALA3110482 | B | Inhibition of TLR4 in C57BL/6 mouse BMDC assessed as reduction of LPS-induced TNF-alpha production at 5 ug/mL preincubated for 2 hrs prior to LPS challenge measured after 24 hrs by ELISA | Mus musculus | 1 | ALA3108700 | single protein format | Scientific Literature | |
| 11. | ALA3111035 | F | Antiinflammatory activity in DBA/1 mouse collagen-induced arthritis model assessed as reduction in serum level of IL-17 at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge by ELISA | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature | |
| 12. | ALA3111036 | F | Antiinflammatory activity in DBA/1 mouse assessed as reduction in number of PMA/ionomycin-stimulated gammadelta+ T cells expressing IL-17 at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge by flow cytometric analysis relative to control | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature | |
| 13. | ALA3111037 | F | Antiinflammatory activity in DBA/1 mouse collagen-induced arthritis model assessed as reduction in number of PMA/ionomycin-stimulated CD4+ T cells expressing IL-17 at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge by flow cytometric analysis relative to control | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature | |
| 14. | ALA3111038 | F | Antiinflammatory activity in DBA/1 mouse collagen-induced arthritis model assessed as reduction in number of PMA/ionomycin-stimulated total DLN cells expressing IL-17 at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge by flow cytometric analysis relative to control | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature | |
| 15. | ALA3111039 | F | Antiinflammatory activity in DBA/1 mouse collagen-induced arthritis model assessed as effect on number of PMA/ionomycin-stimulated gammadelta+ T cells expressing IFNgamma at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge by flow cytometric analysis relative to control | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature | |
| 16. | ALA3111040 | F | Antiinflammatory activity in DBA/1 mouse collagen-induced arthritis model assessed as reduction in number of PMA/ionomycin-stimulated CD4+ T cells expressing IFNgamma at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge by flow cytometric analysis relative to control | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature | |
| 17. | ALA3111041 | F | Antiinflammatory activity in DBA/1 mouse collagen-induced arthritis model assessed as reduction in number of PMA/ionomycin-stimulated CD8+ T cells expressing IFNgamma at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge by flow cytometric analysis relative to control | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature | |
| 18. | ALA3111042 | F | Antiinflammatory activity in DBA/1 mouse collagen-induced arthritis model assessed as reduction in number of PMA/ionomycin-stimulated total DLN cells expressing IFNgamma at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge by flow cytometric analysis relative to control | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature | |
| 19. | ALA3111043 | F | Antiinflammatory activity in DBA/1 mouse collagen-induced arthritis model assessed as reduction in number of gammadelta+ T cells at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature | |
| 20. | ALA3111044 | F | Antiinflammatory activity in DBA/1 mouse collagen-induced arthritis model assessed as reduction in number of CD8+ T cells at 50 ug/kg, sc administered 2 days prior to collagen challenge continued till day 21 post collagen challenge | Mus musculus | 1 | ALA3108700 | organism-based format | Scientific Literature |
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