# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3111814 | B | Selectivity ratio of IC50 for human recombinant full length HDAC6 to IC50 for human recombinant HDAC4 | Homo sapiens | 4 | ALA3108758 | assay format | Scientific Literature | |
2. | ALA3112160 | A | Apparent passive permeability across apical to basolateral side in MDCK2-MDR1 cells after 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 24 | ALA3108758 | cell-based format | Scientific Literature | |
3. | ALA3112161 | A | Efflux ratio of permeability from basolateral to apical side over apical to basolateral side in MDCK2-MDR1 cells after 1 hr by LC-MS/MS analysis relative to wild-type cells | Canis lupus familiaris | 24 | ALA3108758 | cell-based format | Scientific Literature | |
4. | ALA3112162 | A | Intrinsic clearance in human liver microsomes by LC-MS/MS analysis | Homo sapiens | 28 | ALA3108758 | assay format | Scientific Literature | |
5. | ALA3112163 | A | Intrinsic clearance in mouse liver microsomes by LC-MS/MS analysis | Mus musculus | 29 | ALA3108758 | microsome format | Scientific Literature | |
6. | ALA3112165 | B | Inhibition of human recombinant full length HDAC1 using (Ac)Arg-Gly-Lys(Ac) as substrate after 60 mins by fluorescence assay | Homo sapiens | 7 | ALA3108758 | single protein format | Scientific Literature | |
7. | ALA3112166 | B | Inhibition of HDAC4 in human Jurkat E6.1 cells using Boc-Lys-Ac as substrate incubated for 2 hrs prior to substrate addition measured after 3 hrs by fluorescence assay | Homo sapiens | 51 | ALA3108758 | cell-based format | Scientific Literature | |
8. | ALA3112167 | B | Inhibition of HDAC4 in human Jurkat E6.1 cells using Boc-Lys-TFA as substrate incubated for 2 hrs prior to substrate addition measured after 3 hrs by fluorescence assay | Homo sapiens | 51 | ALA3108758 | cell-based format | Scientific Literature | |
9. | ALA3112168 | B | Inhibition of human recombinant full length HDAC8 using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | Homo sapiens | 14 | ALA3108758 | single protein format | Scientific Literature | |
10. | ALA3112169 | B | Inhibition of human recombinant full length HDAC6 after 60 mins by fluorescence assay | Homo sapiens | 9 | ALA3108758 | single protein format | Scientific Literature | |
11. | ALA3112170 | B | Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assay | Homo sapiens | 14 | ALA3108758 | single protein format | Scientific Literature | |
12. | ALA3112171 | B | Inhibition of human recombinant HDAC9 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | Homo sapiens | 14 | ALA3108758 | single protein format | Scientific Literature | |
13. | ALA3112172 | B | Inhibition of human recombinant HDAC7 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | Homo sapiens | 14 | ALA3108758 | single protein format | Scientific Literature | |
14. | ALA3112173 | B | Inhibition of human recombinant HDAC5 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | Homo sapiens | 14 | ALA3108758 | single protein format | Scientific Literature | |
15. | ALA3112174 | B | Inhibition of human recombinant HDAC4 catalytic domain using Boc_Lys_TFA as substrate after 60 mins by fluorescence assay | Homo sapiens | 52 | ALA3108758 | single protein format | Scientific Literature | |
16. | ALA3796125 | B | Inhibition of HDAC4 in human Jurkat E6-1 cells using Lys-TFA as substrate | Homo sapiens | 14 | ALA3792315 | cell-based format | Scientific Literature | |
17. | ALA3796126 | P | Kinetic solubility of the compound | 14 | ALA3792315 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA3796127 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 14 | ALA3792315 | tissue-based format | Scientific Literature | |
19. | ALA3796128 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 14 | ALA3792315 | tissue-based format | Scientific Literature | |
20. | ALA3796129 | A | Apparent permeability across apical to basolateral side in MDCK cells expressing MDR1 | Canis lupus familiaris | 14 | ALA3792315 | cell-based format | Scientific Literature |