| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3112319 | B | Noncompetitive inhibition of nicotine-induced rat alpha4beta2 nAChR transfected in HEK293 cells assessed as stimulation of membrane potential at 3 uM after 10 mins by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA3112320 | B | Noncompetitive inhibition of nicotine-induced rat alpha4beta2 nAChR transfected in HEK293 cells assessed as stimulation of membrane potential at 1 uM after 10 mins by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA3112321 | B | Selectivity ratio of Ki for rat alpha3beta4 nAChR to Ki for rat alpha4beta2 nAChR | Rattus norvegicus | 11 | assay format | Scientific Literature | ||
| 4. | ALA3112322 | B | Inverse agonist activity at nicotine-induced rat alpha4beta2 nAChR activation transfected in HEK293 cells | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3112323 | B | Noncompetitive inhibition of nicotine-induced rat alpha4beta2 nAChR transfected in HEK293 cells assessed as stimulation of membrane potential after 10 mins by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3112324 | B | Noncompetitive inhibition of nicotine-induced rat alpha4beta2 nAChR transfected in HEK293 cells assessed as stimulation of membrane potential at 0.3 uM after 10 mins by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA3112325 | B | Antagonist activity at rat alpha3beta4 nAChR transfected in HEK293 cells assessed as inhibition of nicotine-induced membrane potential stimulation at 10 uM after 10 mins by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3112326 | B | Agonist activity at rat alpha4beta2 nAChR transfected in HEK293 cells assessed as change in membrane potential measured every 3 secs for 120 secs by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA3112327 | B | Agonist activity at rat alpha3beta4 nAChR transfected in HEK293 cells assessed as change in membrane potential measured every 3 secs for 120 secs by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA3112328 | B | Binding affinity to alpha3beta4alpha5 nAChR (unknown origin) | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 11. | ALA3112329 | B | Antagonist activity at rat alpha4beta2 nAChR transfected in HEK293 cells after 10 mins by fluorescence assay in presence of nicotine | Rattus norvegicus | 11 | cell-based format | Scientific Literature | ||
| 12. | ALA3112330 | B | Selectivity ratio for rat alpha3beta4 nAChR transfected in HEK293 cells to rat alpha4beta2 nAChR transfected in HEK293 cells | Rattus norvegicus | 19 | cell-based format | Scientific Literature | ||
| 13. | ALA3112331 | B | Displacement of [3H]epibatidine from rat alpha4beta2 nAChR transfected in HEK293 cells after 2 hrs by beta-plate counting analysis | Rattus norvegicus | 27 | cell-based format | Scientific Literature | ||
| 14. | ALA3112332 | B | Displacement of [3H]epibatidine from rat alpha3beta4 nAChR transfected in HEK293 cells after 2 hrs by beta-plate counting analysis | Rattus norvegicus | 27 | cell-based format | Scientific Literature |
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