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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA3110732 Functional Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E infected in acute C57BL6J (B6) mouse HAT model assessed as day of parasitemia relapse at 5 mg/kg, po qd administered for 5 days in presence of deoxycoformycin Trypanosoma brucei brucei 1 ALA3108778 organism-based format Scientific Literature 2. ALA3110733 Functional Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E infected in acute C57BL6J (B6) mouse HAT model assessed as day of parasitemia relapse at 5 mg/kg, po qd administered for 5 days Trypanosoma brucei brucei 1 ALA3108778 organism-based format Scientific Literature 3. ALA3110734 Functional Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E infected in acute C57BL6J (B6) mouse HAT model assessed as day of parasitemia relapse at 1 mg/kg, po bid administered for 5 days Trypanosoma brucei brucei 1 ALA3108778 organism-based format Scientific Literature 4. ALA3110735 ADME Apparent terminal half life in C57BL/6 mouse at 25 mg/kg, ip Mus musculus 1 ALA3108778 organism-based format Scientific Literature 5. ALA3110736 ADME Apparent terminal half life in C57BL/6 mouse at 25 mg/kg, po Mus musculus 1 ALA3108778 organism-based format Scientific Literature 6. ALA3110737 ADME Apparent initial half life in C57BL/6 mouse at 25 mg/kg, po Mus musculus 1 ALA3108778 organism-based format Scientific Literature 7. ALA3110738 ADME Apparent initial half life in C57BL/6 mouse at 25 mg/kg, ip Mus musculus 1 ALA3108778 organism-based format Scientific Literature 8. ALA3110739 ADME Cmax in C57BL/6 mouse at 25 mg/kg, ip Mus musculus 1 ALA3108778 organism-based format Scientific Literature 9. ALA3110740 ADME Cmax in C57BL/6 mouse at 25 mg/kg, po Mus musculus 1 ALA3108778 organism-based format Scientific Literature 10. ALA3110741 ADME Tmax in C57BL/6 mouse at 25 mg/kg, po and ip Mus musculus 1 ALA3108778 organism-based format Scientific Literature 11. ALA3110742 ADME Fraction unbound in human plasma at 10 uM after 4 hrs by equilibrium dialysis method Homo sapiens 1 ALA3108778 cell-free format Scientific Literature 12. ALA3110743 ADME Metabolic stability in CD-1 mouse liver microsomes at 1 uM by LC-MS/MS analysis Mus musculus 1 ALA3108778 microsome format Scientific Literature 13. ALA3110744 ADME Efflux ratio of apparent permeability across apical to basolateral side over basolateral to apical side in human Caco2 cells at 10 uM by LC-MS/MS analysis Homo sapiens 1 ALA3108778 cell-based format Scientific Literature 14. ALA3110745 ADME Metabolic stability in human liver microsomes at 1 uM by LC-MS/MS analysis Homo sapiens 1 ALA3108778 assay format Scientific Literature 15. ALA3110746 ADME Apparent permeability across basolateral to apical side in human Caco2 cells assessed as compound recovery at 10 uM by LC-MS/MS analysis Homo sapiens 1 ALA3108778 cell-based format Scientific Literature 16. ALA3110747 ADME Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM by LC-MS/MS analysis Homo sapiens 1 ALA3108778 cell-based format Scientific Literature 17. ALA3110748 ADME Apparent permeability across apical to basolateral side in human Caco2 cells assessed as compound recovery at 10 uM by LC-MS/MS analysis Homo sapiens 1 ALA3108778 cell-based format Scientific Literature 18. ALA3110749 ADME Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM by LC-MS/MS analysis Homo sapiens 1 ALA3108778 cell-based format Scientific Literature 19. ALA3110750 ADME Metabolic stability in human plasma at 10 uM measured over 4 hrs by LC-MS/MS analysis Homo sapiens 1 ALA3108778 cell-free format Scientific Literature 20. ALA3110751 Functional Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E after 72 hrs by WST-1 assay in presence of adenosine kinase inhibitor ABT702 Trypanosoma brucei brucei 2 ALA3108778 organism-based format Scientific Literature