| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3110732 | F | Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E infected in acute C57BL6J (B6) mouse HAT model assessed as day of parasitemia relapse at 5 mg/kg, po qd administered for 5 days in presence of deoxycoformycin | Trypanosoma brucei brucei | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA3110733 | F | Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E infected in acute C57BL6J (B6) mouse HAT model assessed as day of parasitemia relapse at 5 mg/kg, po qd administered for 5 days | Trypanosoma brucei brucei | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA3110734 | F | Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E infected in acute C57BL6J (B6) mouse HAT model assessed as day of parasitemia relapse at 1 mg/kg, po bid administered for 5 days | Trypanosoma brucei brucei | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA3110735 | A | Apparent terminal half life in C57BL/6 mouse at 25 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA3110736 | A | Apparent terminal half life in C57BL/6 mouse at 25 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA3110737 | A | Apparent initial half life in C57BL/6 mouse at 25 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA3110738 | A | Apparent initial half life in C57BL/6 mouse at 25 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA3110739 | A | Cmax in C57BL/6 mouse at 25 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA3110740 | A | Cmax in C57BL/6 mouse at 25 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA3110741 | A | Tmax in C57BL/6 mouse at 25 mg/kg, po and ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA3110742 | A | Fraction unbound in human plasma at 10 uM after 4 hrs by equilibrium dialysis method | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 12. | ALA3110743 | A | Metabolic stability in CD-1 mouse liver microsomes at 1 uM by LC-MS/MS analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 13. | ALA3110744 | A | Efflux ratio of apparent permeability across apical to basolateral side over basolateral to apical side in human Caco2 cells at 10 uM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3110745 | A | Metabolic stability in human liver microsomes at 1 uM by LC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA3110746 | A | Apparent permeability across basolateral to apical side in human Caco2 cells assessed as compound recovery at 10 uM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3110747 | A | Apparent permeability across basolateral to apical side in human Caco2 cells at 10 uM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3110748 | A | Apparent permeability across apical to basolateral side in human Caco2 cells assessed as compound recovery at 10 uM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3110749 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA3110750 | A | Metabolic stability in human plasma at 10 uM measured over 4 hrs by LC-MS/MS analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 20. | ALA3110751 | F | Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E after 72 hrs by WST-1 assay in presence of adenosine kinase inhibitor ABT702 | Trypanosoma brucei brucei | 2 | organism-based format | Scientific Literature |
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