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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA3119602 ADME Drug metabolism in human liver microsomes assessed as oxidation of bicyclic morpholine ring Homo sapiens 1 ALA3112561 assay format Scientific Literature 2. ALA3119603 ADME Drug metabolism in rat liver microsomes assessed as oxidation of bicyclic morpholine ring Rattus norvegicus 1 ALA3112561 assay format Scientific Literature 3. ALA3119604 ADME Unbound maximum concentration in C57Bl6 mouse at 100 mg/kg, po Mus musculus 1 ALA3112561 organism-based format Scientific Literature 4. ALA3119605 Unassigned Ratio of EC50 for induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes to ratio of unbound maximum concentration in C57Bl6 mouse Mus musculus 1 ALA3112561 cell-based format Scientific Literature 5. ALA3119623 ADME Fraction unbound in rat plasma at 10 mg/kg, po by rapid equilibrium dialysis method Rattus norvegicus 4 ALA3112561 organism-based format Scientific Literature 6. ALA3119624 ADME Mean residence time in rat at 10 mg/kg, po Rattus norvegicus 5 ALA3112561 organism-based format Scientific Literature 7. ALA3119625 ADME Oral bioavailability in rat at 10 mg/kg Rattus norvegicus 5 ALA3112561 organism-based format Scientific Literature 8. ALA3119626 ADME Clearance in rat at 2 mg/kg, iv Rattus norvegicus 5 ALA3112561 organism-based format Scientific Literature 9. ALA3119627 ADME Volume of distribution at steady state in rat at 2 mg/kg, iv Rattus norvegicus 5 ALA3112561 organism-based format Scientific Literature 10. ALA3119629 ADME Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH Homo sapiens 22 ALA3112561 assay format Scientific Literature 11. ALA3119630 Binding Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay Mus musculus 30 ALA3112561 cell-based format Scientific Literature 12. ALA3131511 Toxicity Toxicity in Zucker diabetic fatty rat assessed as change in plasma triglyceride level Rattus norvegicus 1 ALA3124752 organism-based format Scientific Literature 13. ALA3131512 Toxicity Toxicity in Zucker diabetic fatty rat assessed as change in plasma insulin level Rattus norvegicus 1 ALA3124752 organism-based format Scientific Literature 14. ALA3131513 Toxicity Toxicity in Wistar rat assessed as induction of hypoglycemia at 100 mg/kg, po Rattus norvegicus 1 ALA3124752 organism-based format Scientific Literature 15. ALA3131514 Functional Glucose lowering effect in Wistar rat at 100 mg/kg, po Rattus norvegicus 1 ALA3124752 organism-based format Scientific Literature 16. ALA3131515 Functional Antidiabetic activity in Zucker diabetic fatty rat assessed as glucose lowering effect at 30 to 100 mg/kg, po Rattus norvegicus 1 ALA3124752 organism-based format Scientific Literature 17. ALA3131516 Functional Disruption of GKRP-GK interaction in po dosed Zucker diabetic fatty rat assessed as effect on GK translocation measured after 1 hr by immunohistochemical analysis Rattus norvegicus 1 ALA3124752 organism-based format Scientific Literature 18. ALA3131517 ADME fCmax in Wistar rat at 100 mg/kg, po Rattus norvegicus 1 ALA3124752 organism-based format Scientific Literature 19. ALA3131518 ADME fCmax in Sprague-Dawley rat Rattus norvegicus 1 ALA3124752 organism-based format Scientific Literature 20. ALA3131519 ADME Fraction unbound in Sprague-Dawley rat plasma at 2 mg/kg, iv and 10 mg/kg, po Rattus norvegicus 2 ALA3124752 organism-based format Scientific Literature