| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3119602 | A | Drug metabolism in human liver microsomes assessed as oxidation of bicyclic morpholine ring | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA3119603 | A | Drug metabolism in rat liver microsomes assessed as oxidation of bicyclic morpholine ring | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 3. | ALA3119604 | A | Unbound maximum concentration in C57Bl6 mouse at 100 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA3119605 | U | Ratio of EC50 for induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes to ratio of unbound maximum concentration in C57Bl6 mouse | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3119623 | A | Fraction unbound in rat plasma at 10 mg/kg, po by rapid equilibrium dialysis method | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 6. | ALA3119624 | A | Mean residence time in rat at 10 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 7. | ALA3119625 | A | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 8. | ALA3119626 | A | Clearance in rat at 2 mg/kg, iv | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 9. | ALA3119627 | A | Volume of distribution at steady state in rat at 2 mg/kg, iv | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 10. | ALA3119629 | A | Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH | Homo sapiens | 22 | assay format | Scientific Literature | ||
| 11. | ALA3119630 | B | Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay | Mus musculus | 30 | cell-based format | Scientific Literature | ||
| 12. | ALA3131511 | T | Toxicity in Zucker diabetic fatty rat assessed as change in plasma triglyceride level | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3131512 | T | Toxicity in Zucker diabetic fatty rat assessed as change in plasma insulin level | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3131513 | T | Toxicity in Wistar rat assessed as induction of hypoglycemia at 100 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3131514 | F | Glucose lowering effect in Wistar rat at 100 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3131515 | F | Antidiabetic activity in Zucker diabetic fatty rat assessed as glucose lowering effect at 30 to 100 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3131516 | F | Disruption of GKRP-GK interaction in po dosed Zucker diabetic fatty rat assessed as effect on GK translocation measured after 1 hr by immunohistochemical analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3131517 | A | fCmax in Wistar rat at 100 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3131518 | A | fCmax in Sprague-Dawley rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3131519 | A | Fraction unbound in Sprague-Dawley rat plasma at 2 mg/kg, iv and 10 mg/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature |
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