# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3119628 | ADME | Intrinsic clearance in rat liver microsomes at 1 uM after 30 mins in presence of NADPH | Rattus norvegicus | 30 | ALA3112561 | assay format | Scientific Literature | |
2. | ALA3119630 | Binding | Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay | Mus musculus | 30 | ALA3112561 | cell-based format | Scientific Literature | |
3. | ALA3117036 | Binding | Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by Alpha Screen assay | Homo sapiens | 30 | ALA3112561 | single protein format | Scientific Literature | |
4. | ALA3131519 | ADME | Fraction unbound in Sprague-Dawley rat plasma at 2 mg/kg, iv and 10 mg/kg, po | Rattus norvegicus | 2 | ALA3124752 | organism-based format | Scientific Literature | |
5. | ALA3131520 | ADME | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 2 | ALA3124752 | organism-based format | Scientific Literature | |
6. | ALA3131521 | ADME | Cmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA3124752 | organism-based format | Scientific Literature | |
7. | ALA3131522 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 2 | ALA3124752 | organism-based format | Scientific Literature | |
8. | ALA3131523 | ADME | Clearance in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 2 | ALA3124752 | organism-based format | Scientific Literature | |
9. | ALA3131524 | ADME | Intrinsic clearance in Sprague-Dawley rat liver microsomes at 1 uM after 30 mins in presence of NADPH | Rattus norvegicus | 2 | ALA3124752 | assay format | Scientific Literature | |
10. | ALA3131525 | Binding | Activation of human glucokinase | Homo sapiens | 2 | ALA3124752 | single protein format | Scientific Literature | |
11. | ALA3131526 | Binding | Binding affinity to GKRP (unknown origin) by surface plasmon resonance analysis | Homo sapiens | 1 | ALA3124752 | single protein format | Scientific Literature | |
12. | ALA3131527 | Binding | Inhibition of GKRP-GK interaction in rat primary hepatocytes assessed as translocation of GK from nucleus to cytoplasm preincubated for 20 mins followed by glucose addition measured after 40 mins by fluorescence assay | Rattus norvegicus | 8 | ALA3124752 | cell-based format | Scientific Literature | |
13. | ALA3131528 | Binding | Inhibition of biotin-tagged human GKRP-fluorescein-tagged human GK interaction preincubated for 20 mins followed by fluorescein-tagged human GK addition measured after 2 to 4 hrs by AlphaScreen assay | Homo sapiens | 24 | ALA3124752 | single protein format | Scientific Literature |