# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3118146 | F | Antibacterial activity against Escherichia coli RP437 expressing red fluorescence protein assessed as inhibition of biofilm formation measured as reduction in surface area at 200 uM after 24 hrs by confocal laser scanning microscopic analysis | Escherichia coli | 4 | ALA3112522 | organism-based format | Scientific Literature | |
2. | ALA3118147 | F | Antibacterial activity against Escherichia coli RP437 expressing red fluorescence protein assessed as inhibition of biofilm formation measured as reduction in mean thickness of biofilm at 200 uM after 24 hrs by confocal laser scanning microscopic analysis | Escherichia coli | 4 | ALA3112522 | organism-based format | Scientific Literature | |
3. | ALA3118148 | F | Antibacterial activity against Escherichia coli RP437 expressing red fluorescence protein assessed as inhibition of biofilm formation measured as reduction in biomass at 200 uM after 24 hrs by confocal laser scanning microscopic analysis | Escherichia coli | 4 | ALA3112522 | organism-based format | Scientific Literature | |
4. | ALA3118149 | A | Cytotoxicity against human SK-N-SH cells assessed as cell survival at 100 uM incubated for 1 hr followed by compound washout measured up to 48 hrs by CCK-8 assay | Homo sapiens | 4 | ALA3112522 | cell-based format | Scientific Literature | |
5. | ALA3118150 | A | Cytotoxicity against human SK-N-SH cells assessed as cell survival at 400 uM incubated for 1 hr followed by compound washout measured after 48 hrs by CCK-8 assay relative to control | Homo sapiens | 4 | ALA3112522 | cell-based format | Scientific Literature | |
6. | ALA3118151 | A | Cytotoxicity against human SK-N-SH cells assessed as cell survival at 400 uM incubated for 1 hr followed by compound washout measured after 24 hrs by CCK-8 assay relative to control | Homo sapiens | 4 | ALA3112522 | cell-based format | Scientific Literature | |
7. | ALA3118152 | A | Cytotoxicity against human SK-N-SH cells assessed as cell survival at 400 uM incubated for 1 hr followed by compound washout measured immediately by CCK-8 assay relative to control | Homo sapiens | 4 | ALA3112522 | cell-based format | Scientific Literature | |
8. | ALA3118156 | B | Agonist activity at RhlR in Pseudomonas aeruginosa PAO1 expressing RhlI assessed as effect on GFP production at 50 to 300 uM after 24 hrs by fluorescence assay relative to control | Pseudomonas aeruginosa PAO1 | 3 | ALA3112522 | single protein format | Scientific Literature | |
9. | ALA3118159 | B | Antagonist activity at LasR in Pseudomonas aeruginosa PAO-JP2 expressing LasI assessed as inhibition of GFP production at 50 to 300 uM after 24 hrs by fluorescence assay in presence of 3-oxo-C12-HSL | Pseudomonas aeruginosa | 4 | ALA3112522 | single protein format | Scientific Literature | |
10. | ALA3118160 | B | Antagonist activity at LasR in Pseudomonas aeruginosa PAO1 expressing LasI assessed as inhibition of GFP production at 50 to 300 uM after 24 hrs by fluorescence assay relative to control | Pseudomonas aeruginosa PAO1 | 2 | ALA3112522 | single protein format | Scientific Literature | |
11. | ALA3118163 | A | Toxicity in Escherichia coli RP437 assessed as planktonic growth inhibition at 200 uM up to 8 hrs | Escherichia coli | 1 | ALA3112522 | organism-based format | Scientific Literature | |
12. | ALA3119336 | F | Antibacterial activity against Escherichia coli RP437 expressing red fluorescence protein assessed as inhibition of biofilm formation at 200 uM after 24 hrs by confocal laser scanning microscopic analysis | Escherichia coli | 4 | ALA3112522 | organism-based format | Scientific Literature | |
13. | ALA3226285 | F | Ratio of inhibition of biofilm formation in sdiA-knockout Escherichia coli AY1297 to inhibition of biofilm formation in wild-type Escherichia coli RP437 | Escherichia coli | 2 | ALA3217670 | organism-based format | Scientific Literature | |
14. | ALA3224756 | B | Agonist activity at Pseudomonas aeruginosa PAO1 RhlR expressing rhlI coexpressing LVA-GFP at 100 to 200 uM after 24 hrs by fluorescence assay | Pseudomonas aeruginosa PAO1 | 2 | ALA3217670 | single protein format | Scientific Literature | |
15. | ALA3224757 | B | Antagonist activity at Pseudomonas aeruginosa PAO1 LasR expressing lasI coexpressing LVA-GFP at 100 to 200 uM after 24 hrs by fluorescence assay | Pseudomonas aeruginosa PAO1 | 2 | ALA3217670 | single protein format | Scientific Literature | |
16. | ALA3224758 | B | Inhibition of quorum sensing system-mediated elastase B production in Pseudomonas aeruginosa PAO1 at 200 uM after 24 hrs by colorimetric assay relative to control | Pseudomonas aeruginosa PAO1 | 2 | ALA3217670 | assay format | Scientific Literature | |
17. | ALA3224761 | F | Inhibition of biofilm formation in wild-type Pseudomonas aeruginosa PAO1 expressing red fluorescent protein assessed as reduction in biomass at 200 uM after 24 hrs by confocal laser scanning microscopic analysis relative to control | Pseudomonas aeruginosa | 2 | ALA3217670 | organism-based format | Scientific Literature | |
18. | ALA3224762 | F | Inhibition of biofilm formation in wild-type Pseudomonas aeruginosa PAO1 at 200 uM after 24 hrs by crystal violet staining-based assay relative to control | Pseudomonas aeruginosa | 2 | ALA3217670 | organism-based format | Scientific Literature | |
19. | ALA3224763 | F | Inhibition of biofilm formation in sdiA-knockout Escherichia coli AY1297 at 200 uM after 24 hrs by scanning electron microscopic analysis | Escherichia coli | 1 | ALA3217670 | organism-based format | Scientific Literature | |
20. | ALA3224768 | F | Inhibition of biofilm formation in wild-type Escherichia coli RP437 at 200 uM after 24 hrs by scanning electron microscopic analysis | Escherichia coli | 1 | ALA3217670 | organism-based format | Scientific Literature |