| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3124055 | B | Inhibition of Hepatitis C virus genotype 1b NS3/4A protease D168Y mutant assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition by time-resolved fluorescence assay | Hepatitis C virus subtype 1b | 25 | ALA3120153 | assay format | Scientific Literature | |
| 2. | ALA3124056 | B | Inhibition of Hepatitis C virus genotype 1b NS3/4A protease A156V mutant assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition by time-resolved fluorescence assay | Hepatitis C virus subtype 1b | 25 | ALA3120153 | assay format | Scientific Literature | |
| 3. | ALA3124057 | B | Inhibition of Hepatitis C virus genotype 1b NS3/4A protease A156T mutant assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition by time-resolved fluorescence assay | Hepatitis C virus subtype 1b | 25 | ALA3120153 | assay format | Scientific Literature | |
| 4. | ALA3124059 | B | Inhibition of Hepatitis C virus genotype 1b NS3/4A protease R155K mutant assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition by time-resolved fluorescence assay | Hepatitis C virus subtype 1b | 25 | ALA3120153 | assay format | Scientific Literature | |
| 5. | ALA3124060 | F | Antiviral activity against Hepatitis C virus genotype 3a infected in HuH7 cells assessed as reduction in replicon RNA level after 72 hrs by TaqMan-based RT-PCR analysis in presence of 10% FBS | Hepacivirus hominis | 7 | ALA3120153 | organism-based format | Scientific Literature | |
| 6. | ALA3124061 | F | Antiviral activity against Hepatitis C virus genotype 1b infected in HuH7 cells assessed as reduction in replicon RNA level after 72 hrs by TaqMan-based RT-PCR analysis in presence of 10% FBS | Hepacivirus hominis | 7 | ALA3120153 | organism-based format | Scientific Literature | |
| 7. | ALA3124062 | A | AUC in rat at 5 mg/kg, po | Rattus norvegicus | 8 | ALA3120153 | organism-based format | Scientific Literature | |
| 8. | ALA3124063 | B | Inhibition of Hepatitis C virus genotype 3a NS3/4A protease assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition by time-resolved fluorescence assay | Hepatitis C virus subtype 3a | 25 | ALA3120153 | assay format | Scientific Literature | |
| 9. | ALA3124064 | B | Inhibition of Hepatitis C virus genotype 1b NS3/4A protease assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition by time-resolved fluorescence assay | Hepatitis C virus subtype 1b | 25 | ALA3120153 | assay format | Scientific Literature |
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