# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3124112 | A | Oral absorption in beagle dog at 5 mg/kg, po by LC/MS/MS analysis | Canis lupus familiaris | 7 | organism-based format | Scientific Literature | ||
2. | ALA3124113 | A | AUC (0 to infinity) in jagular vein cannulated beagle dog at 0.5 mg/kg, iv by LC/MS/MS analysis | Canis lupus familiaris | 5 | organism-based format | Scientific Literature | ||
3. | ALA3124114 | A | AUC (0 to infinity) in portal vein cannulated beagle dog at 0.5 mg/kg, iv by LC/MS/MS analysis | Canis lupus familiaris | 5 | organism-based format | Scientific Literature | ||
4. | ALA3124115 | A | Oral bioavailability in golden syrian hamster at 5 mg/kg | Mesocricetus auratus | 6 | organism-based format | Scientific Literature | ||
5. | ALA3124116 | A | Cmax in golden syrian hamster assessed as liver triphosphate level at 5 mg/kg, po by LC/MS/MS analysis | Mesocricetus auratus | 11 | organism-based format | Scientific Literature | ||
6. | ALA3124117 | A | Cmax in golden syrian hamster assessed as liver triphosphate level at 1 mg/kg, iv by LC/MS/MS analysis | Mesocricetus auratus | 11 | organism-based format | Scientific Literature | ||
7. | ALA3124268 | A | Prodrug coversion in human hepatocytes assessed as triphosphate formation assesed per million cells at 10 uM incubated for 1 hr followed by compound washout by liquid chromatography coupled with mass spectrometry | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
8. | ALA3124269 | A | Metabolic stability in human liver S9 fraction assessed as extraction at 2 uM after 90 mins by LC/MS/MS analysis | Homo sapiens | 10 | subcellular format | Scientific Literature | ||
9. | ALA3124270 | A | Half life in human intestinal S9 fraction at 2 uM by LC/MS/MS analysis | Homo sapiens | 10 | assay format | Scientific Literature | ||
10. | ALA3124271 | A | Permeability across basolateral to apical side in human Caco2 cells at 10 uM after 1 to 2 hrs by LC/MS/MS analysis | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
11. | ALA3124272 | A | Permeability across apical to basolateral side in human Caco2 cells at 10 uM after 1 to 2 hrs by LC/MS/MS analysis | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
12. | ALA3124273 | P | Aqueous solubility of the compound in phosphate buffer at pH 7 by reverse-phase UPLC-UV method | 10 | small-molecule physicochemical format | Scientific Literature | |||
13. | ALA3124274 | P | Lipophilicity, log D of the compound by HPLC/UV method | 12 | small-molecule physicochemical format | Scientific Literature | |||
14. | ALA3124276 | A | Cytotoxicity against human HuH7 cells after 3 days by fluorescence assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
15. | ALA3124279 | F | Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay | Hepacivirus hominis | 15 | organism-based format | Scientific Literature | ||
16. | ALA4008247 | F | Antiviral activity against Ebolavirus Kikwit infected in human HeLa cells assessed as reduction in viral glycoprotein levels preincubated with cells for 2 hrs followed by viral infection measured after 48 hrs by immunostaining based assay | Ebolavirus | 22 | cell-based format | Scientific Literature | ||
17. | ALA4008248 | F | Antiviral activity against GFP-fused Ebolavirus infected in TERT-immortalized HMVEC assessed as reduction in viral replication preincubated with cells followed by viral infection measured after 3 to 4 days by fluorescence assay | Ebolavirus | 24 | assay format | Scientific Literature | ||
18. | ALA4008249 | F | Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay | Human respiratory syncytial virus | 13 | cell-based format | Scientific Literature | ||
19. | ALA4008250 | F | Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells preincubated with cells for 3 days followed by viral infection by luciferase assay | Hepacivirus hominis | 14 | cell-based format | Scientific Literature | ||
20. | ALA4008251 | A | Cytotoxicity against human Hep2 cells assessed as reduction in cell viability after 4 to 5 days by Cell-Titer Glo assay | Homo sapiens | 13 | cell-based format | Scientific Literature |