| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3124116 | A | Cmax in golden syrian hamster assessed as liver triphosphate level at 5 mg/kg, po by LC/MS/MS analysis | Mesocricetus auratus | 11 | organism-based format | Scientific Literature | ||
| 2. | ALA3124117 | A | Cmax in golden syrian hamster assessed as liver triphosphate level at 1 mg/kg, iv by LC/MS/MS analysis | Mesocricetus auratus | 11 | organism-based format | Scientific Literature | ||
| 3. | ALA3124268 | A | Prodrug coversion in human hepatocytes assessed as triphosphate formation assesed per million cells at 10 uM incubated for 1 hr followed by compound washout by liquid chromatography coupled with mass spectrometry | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 4. | ALA3124269 | A | Metabolic stability in human liver S9 fraction assessed as extraction at 2 uM after 90 mins by LC/MS/MS analysis | Homo sapiens | 10 | subcellular format | Scientific Literature | ||
| 5. | ALA3124270 | A | Half life in human intestinal S9 fraction at 2 uM by LC/MS/MS analysis | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 6. | ALA3124271 | A | Permeability across basolateral to apical side in human Caco2 cells at 10 uM after 1 to 2 hrs by LC/MS/MS analysis | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 7. | ALA3124272 | A | Permeability across apical to basolateral side in human Caco2 cells at 10 uM after 1 to 2 hrs by LC/MS/MS analysis | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 8. | ALA3124273 | P | Aqueous solubility of the compound in phosphate buffer at pH 7 by reverse-phase UPLC-UV method | 10 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA3124274 | P | Lipophilicity, log D of the compound by HPLC/UV method | 12 | small-molecule physicochemical format | Scientific Literature | |||
| 10. | ALA3124276 | A | Cytotoxicity against human HuH7 cells after 3 days by fluorescence assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 11. | ALA3124279 | F | Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luminescence assay | Hepacivirus hominis | 15 | organism-based format | Scientific Literature |
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