| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3124490 | F | Ratio of IC50 to KD for mGluR5 receptor in sc dosed Sprague-Dawley rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA3124491 | F | Binding affinity to mGluR5 receptor in sc dosed Sprague-Dawley rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA3124492 | A | Therapeutic index in cynomolgus monkey | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA3124493 | A | Therapeutic index in cynomolgus monkey 50 mg/kg/day, po | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA3124494 | A | Therapeutic index in cynomolgus monkey 150 mg/kg/day, po | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA3124495 | T | Toxicity in cynomolgus monkey assessed as appearance of erythematous skin lesions at <= 150 mg/kg/day, po after 9 days | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA3124496 | A | Therapeutic index in rat at 80 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA3124497 | T | Toxicity in rat at <= 100 mg/kg/day, po after 90 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA3124498 | A | Therapeutic index in cynomolgus monkey after 24 hrs | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA3124499 | T | Toxicity in cynomolgus monkey at <= 75 mg/kg/day, po after 14 days | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA3124500 | T | Toxicity in rat at <= 80 mg/kg/day, po after 14 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA3124501 | F | Modulation of excessive glutamate release in basal ganglia of cynomolgus monkey MPTP-rendered Parkinsonian L-DOPA-induced dyskinesia model | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3124502 | F | Antiparkinsonian effect in cynomolgus monkey MPTP-rendered Parkinsonian L-DOPA-induced dyskinesia model assessed as reduction in total disability at 0.32 to 1 mg/kg, sc after 6 hrs | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3124503 | F | Antiparkinsonian effect in cynomolgus monkey MPTP-rendered Parkinsonian L-DOPA-induced dyskinesia model assessed as reduction in dyskinesia at 0.32 to 1 mg/kg, sc after 6 hrs | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3124504 | A | Therapeutic index in rat after 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3124507 | F | In vivo mGluR5 receptor occupancy in cynomolgus monkey assessed as inhibition of [18F]FPEB binding administered as iv bolus at 30 mins prior to [18F]FPEB- injection followed by constant infusion for 120 mins by PET analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3124508 | T | Toxicity in cynomolgus monkey assessed as delayed-type immune-mediated type 4 hypersensitivity at <= 150 mg/kg/day, po after 90 days | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3124509 | F | In vivo mGluR5 receptor occupancy in sc dosed Sprague-Dawley rat brain assessed as inhibition of [3H]MPEPy binding after 60 mins by liquid scintillation counting analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA3124510 | A | Half life in monkey | Macaca mulatta | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3124511 | A | Oral bioavailability in monkey at 30 mg/kg | Macaca mulatta | 1 | organism-based format | Scientific Literature |
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