# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3130589 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as parasite death at IC25 after 96 hrs by transmission electron microscopic analysis | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
2. | ALA3130591 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as damaged glycosomes at IC25 after 96 hrs by transmission electron microscopic analysis | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
3. | ALA3130592 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as damaged mitochondria at IC25 after 96 hrs by transmission electron microscopic analysis | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
4. | ALA3130593 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as large vacuolization with lipidic type vacuoles occupying cytoplasm at IC25 after 96 hrs by transmission electron microscopic analysis | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
5. | ALA3130594 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as presence of little electron-dense cytoplasm at IC25 after 96 hrs by transmission electron microscopic analysis | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
6. | ALA3130595 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as change in ethanol level at IC25 after 96 hrs by [1H]-NMR spectroscopic analysis relative to control | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
7. | ALA3130596 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as change in succinate level at IC25 after 96 hrs by [1H]-NMR spectroscopic analysis relative to control | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
8. | ALA3130793 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as change in acetate level at IC25 after 96 hrs by [1H]-NMR spectroscopic analysis | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
9. | ALA3132178 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as change in L-alanine level at IC25 after 96 hrs by [1H]-NMR spectroscopic analysis relative to control | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
10. | ALA3132179 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes assessed as change in L-lactate level at IC25 after 96 hrs by [1H]-NMR spectroscopic analysis relative to control | Trypanosoma cruzi | 2 | ALA3124881 | organism-based format | Scientific Literature | |
11. | ALA3132180 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) infected in BALB/c mouse assessed as reduction in parasite specific antibodies level at 1 mg/kg/day, ip treated from day 5 to day 10 post-infection measured from day 30 to day 120 post-infection by ELISA | Trypanosoma cruzi | 3 | ALA3124881 | organism-based format | Scientific Literature | |
12. | ALA3132181 | T | Toxicity in BALB/c mouse assessed as mortality at 1 mg/kg/day, ip | Mus musculus | 2 | ALA3124881 | organism-based format | Scientific Literature | |
13. | ALA3132183 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) infected in BALB/c mouse assessed as reduction in parasitemia at 1 mg/kg/day, ip treated from day 5 to day 10 post-infection measured on day 30 post-infection relative to control | Trypanosoma cruzi | 3 | ALA3124881 | organism-based format | Scientific Literature | |
14. | ALA3132184 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) infected in BALB/c mouse assessed as reduction in parasitemia at 1 mg/kg/day, ip treated from day 5 to day 10 post-infection measured on day 14 post-infection | Trypanosoma cruzi | 3 | ALA3124881 | organism-based format | Scientific Literature | |
15. | ALA3132185 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) infected in African green monkey Vero cells assessed as reduction in number of trypomastigotes at IC25 treated for 12 hrs followed by compound-washout measured after 10 days by microscopic analysis relative to control | Trypanosoma cruzi | 3 | ALA3124881 | organism-based format | Scientific Literature | |
16. | ALA3132186 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) infected in African green monkey Vero cells assessed as reduction in infection rate at IC25 treated for 12 hrs followed by compound-washout measured after 10 days by microscopic analysis relative to control | Trypanosoma cruzi | 3 | ALA3124881 | organism-based format | Scientific Literature | |
17. | ALA3132187 | F | Antitrypanosomal activity against Trypanosoma cruzi (IRHOD/CO/2008/SN3) infected in African green monkey Vero cells assessed as reduction in number of amastigotes at IC25 treated for 12 hrs followed by compound-washout measured after 10 days by microscopic analysis relative to control | Trypanosoma cruzi | 3 | ALA3124881 | organism-based format | Scientific Literature | |
18. | ALA3132188 | T | Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for Trypanosoma cruzi (IRHOD/CO/2008/SN3) trypomastigotes | 9 | ALA3124881 | cell-based format | Scientific Literature | ||
19. | ALA3132189 | T | Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for Trypanosoma cruzi (IRHOD/CO/2008/SN3) epimastigotes | 9 | ALA3124881 | cell-based format | Scientific Literature | ||
20. | ALA3132190 | T | Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for Trypanosoma cruzi (IRHOD/CO/2008/SN3) amastigotes | 9 | ALA3124881 | cell-based format | Scientific Literature |