# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3130437 | B | Inhibition of thymidylate synthase in human 2008 cells assessed as [5-3H]dUMP conversion to dTMP after 30 mins by liquid scintillation counting analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA3130597 | B | Inhibition of thymidylate synthase in 13-fold cisplatin-resistant human C13 cells assessed as effect on thymidylate synthase mRNA level at 5 uM after 48 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
3. | ALA3130598 | B | Inhibition of thymidylate synthase in human 2008 cells assessed as upregulation of thymidylate synthase mRNA level at 5 uM after 48 hrs by RT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
4. | ALA3130599 | B | Inhibition of thymidylate synthase in 13-fold cisplatin-resistant human C13 cells assessed as downregulation of DHFR protein level at 5 uM after 48 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA3130600 | B | Inhibition of thymidylate synthase in human 2008 cells assessed as downregulation of DHFR protein level at 5 uM after 48 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA3130605 | F | Cytotoxicity against 10-fold cisplatin-resistant human A2780C/P cells cell survival at 10 uM after 72 hrs by crystal violet staining-based spectrophotometric analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
7. | ALA3130607 | F | Cytotoxicity against 13-fold cisplatin-resistant human C13 cells cell survival at 10 uM after 72 hrs by crystal violet staining-based spectrophotometric analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
8. | ALA3130611 | B | Inhibition of human thymidylate synthase using dUMP as substrate at 100 uM after 1 hr by UV-vis spectrophotometric analysis in presence of mTHF relative to control | Homo sapiens | 17 | single protein format | Scientific Literature | ||
9. | ALA3382533 | F | Growth inhibition of cisplatin-resistant human C13 cells after 72 hrs by flow-cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA3373982 | F | Cytotoxicity against cisplatin-resistant human C13 cells assessed as reduction in cell survival at 1 to 5 uM after 72 hrs by crystal violet assay relative to untreated control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA3373983 | A | Cellular uptake in nucleus of human cisplatin-resistant human C13 cells after 2 hrs by confocal imaging using SAINT-PhD delivery system | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA3373984 | P | Stability in DMEM medium assessed as compound concentration at initial concentration of 6.7 uM measured after 2 hrs by LC-MS/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
13. | ALA3373985 | P | Stability in DMEM medium assessed as compound concentration at initial concentration of 6.7 uM measured after 4 hrs by LC-MS/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
14. | ALA3373986 | P | Stability in DMEM medium assessed as compound concentration at initial concentration of 6.7 uM measured after 6 hrs by LC-MS/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
15. | ALA3374573 | P | Stability in DMEM medium assessed as compound concentration at initial concentration of 6.7 uM measured after 8 hrs by LC-MS/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA3374574 | P | Stability in DMEM medium assessed as compound concentration at initial concentration of 35 uM measured after 2 hrs by LC-MS/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
17. | ALA3374575 | P | Stability in DMEM medium assessed as compound concentration at initial concentration of 35 uM measured after 4 hrs by LC-MS/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
18. | ALA3374576 | P | Stability in DMEM medium assessed as compound concentration at initial concentration of 35 uM measured after 6 hrs by LC-MS/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
19. | ALA3374577 | P | Stability in DMEM medium assessed as compound concentration at initial concentration of 35 uM measured after 8 hrs by LC-MS/MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
20. | ALA3374578 | A | Stability in cisplatin-resistant human C13 cell lysate assessed as compound concentration at initial concentration of 6.7 uM measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |