| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3129940 | F | Antidiabetic activity in Sprague-Dawley rat assessed as urinary glucose excretion at 1 mg/kg, po administered 1 hr prior to glucose challenge measured after 1 to 24 hrs relative to dapagliflozin | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 2. | ALA3129941 | F | Antidiabetic activity in Sprague-Dawley rat assessed as urinary glucose excretion at 1 mg/kg, po administered 1 hr prior to glucose challenge measured after 4 to 24 hrs relative to dapagliflozin | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 3. | ALA3129942 | F | Antidiabetic activity in Sprague-Dawley rat assessed as urinary glucose excretion at 1 mg/kg, po administered 1 hr prior to glucose challenge measured after 1 to 4 hrs relative to dapagliflozin | Rattus norvegicus | 9 | organism-based format | Scientific Literature | ||
| 4. | ALA3130105 | A | Half life in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 5. | ALA3130106 | A | AUC (0 to infinity) in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 6. | ALA3130107 | A | Cmax in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 7. | ALA3130108 | A | Tmax in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 8. | ALA3130109 | B | Selectivity ratio of IC50 for human SGLT2 to IC50 for human SGLT1 | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 9. | ALA3130110 | B | Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation counting analysis | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 10. | ALA3130910 | B | Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation counting analysis | Homo sapiens | 12 | cell-based format | Scientific Literature |
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