# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3130397 | Functional | Induction of mouse bone marrow cell differentiation expressing MLL-AF9 assessed as highly vacuolated cytoplasm at 3 uM after 7 days by Wright-Giemsa staining-based cytospin technique | Mus musculus | 2 | ALA3124794 | cell-based format | Scientific Literature | |
2. | ALA3130398 | Functional | Induction of mouse bone marrow cell differentiation expressing MLL-AF9 assessed as multilobed nuclei at 3 uM after 7 days by Wright-Giemsa staining-based cytospin technique | Mus musculus | 2 | ALA3124794 | cell-based format | Scientific Literature | |
3. | ALA3130399 | Functional | Induction of mouse bone marrow cell differentiation expressing MLL-AF9 assessed as decreased nuclei to cytoplasm ratio at 3 uM after 7 days by Wright-Giemsa staining-based cytospin technique | Mus musculus | 2 | ALA3124794 | cell-based format | Scientific Literature | |
4. | ALA3130400 | Functional | Induction of mouse bone marrow cell differentiation expressing MLL-AF9 assessed as CD11b level at 3 to 6 uM after 6 days by annexin V-FITC and propidium iodide staining-based flow cytometric analysis | Mus musculus | 2 | ALA3124794 | cell-based format | Scientific Literature | |
5. | ALA3130401 | Functional | Growth inhibition of human HL60 cells after 7 days by MTT assay | Homo sapiens | 2 | ALA3124794 | cell-based format | Scientific Literature | |
6. | ALA3130402 | Functional | Growth inhibition of human MOLM13 cells harboring MLL-AF9 after 7 days by MTT assay | Homo sapiens | 2 | ALA3124794 | cell-based format | Scientific Literature | |
7. | ALA3130403 | Functional | Growth inhibition of human MV411 cells harboring MLL-AF4 after 7 days by MTT assay | Homo sapiens | 2 | ALA3124794 | cell-based format | Scientific Literature | |
8. | ALA3130528 | Functional | Growth inhibition of mouse bone marrow cells expressing HM-2 after 7 days by MTT assay | Mus musculus | 2 | ALA3124794 | cell-based format | Scientific Literature | |
9. | ALA3130529 | Functional | Growth inhibition of mouse bone marrow cells expressing MLL-AF9 after 7 days by MTT assay | Mus musculus | 2 | ALA3124794 | cell-based format | Scientific Literature | |
10. | ALA3130533 | Binding | Inhibition of menin-FLAG-tagged MLL-AF9 interaction in mouse bone marrow cells assessed as downregulation of MEIS1 mRNA expression after 6 days by qRT-PCR analysis | Mus musculus | 2 | ALA3124794 | cell-based format | Scientific Literature | |
11. | ALA3130534 | Binding | Inhibition of menin-FLAG-tagged MLL-AF9 interaction in mouse bone marrow cells assessed as downregulation of HOXA9 mRNA expression after 6 days by qRT-PCR analysis | Mus musculus | 2 | ALA3124794 | cell-based format | Scientific Literature | |
12. | ALA3130535 | Functional | Effect on FLAG-tagged MLL-AF9 protein expression in HEK293 cells at 3 to 12 uM after 12 hrs by Western blotting analysis | Homo sapiens | 2 | ALA3124794 | cell-based format | Scientific Literature | |
13. | ALA3130536 | Functional | Effect on menin protein expression in HEK293 cells at 3 to 12 uM after 12 hrs by Western blotting analysis | Homo sapiens | 2 | ALA3124794 | cell-based format | Scientific Literature | |
14. | ALA3130537 | Binding | Inhibition of menin-FLAG-tagged MLL-AF9 interaction in HEK293 cells at 3 to 12 uM after 12 hrs by co-immunoprecipitation assay | Homo sapiens | 2 | ALA3124794 | cell-based format | Scientific Literature | |
15. | ALA3130538 | Binding | Binding affinity to human menin by isothermal titration calorimetric analysis | Homo sapiens | 3 | ALA3124794 | single protein format | Scientific Literature | |
16. | ALA3130541 | Binding | Inhibition of human His-tagged menin-biotinylated MLL (4 to 15) interaction after 1 hr by HTRF assay | Homo sapiens | 29 | ALA3124794 | single protein format | Scientific Literature |