# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3129866 | B | Inhibition of furin in African green monkey Vero cells assessed as protection against Stx-induced toxicity at 2 to 20 uM incubated for 4 hrs prior to Stx challenge measured after 24 hrs by LDH assay | Chlorocebus sabaeus | 3 | ALA3124763 | cell-based format | Scientific Literature | |
2. | ALA3129867 | B | Inhibition of furin (unknown origin) assessed as HA5-mediated membrane fusion at 12.5 to 50 uM after 36 hrs by cell-based luciferase reporter gene assay | Homo sapiens | 3 | ALA3124763 | cell-based format | Scientific Literature | |
3. | ALA3129870 | B | Inhibition of furin in African green monkey Vero cells assessed as protection against Stx-induced toxicity at 80 uM incubated for 4 hrs prior to Stx challenge measured after 24 hrs by LDH assay | Chlorocebus sabaeus | 6 | ALA3124763 | cell-based format | Scientific Literature | |
4. | ALA3129871 | B | Inhibition of furin in African green monkey Vero cells assessed as protection against Stx-induced toxicity incubated for 4 hrs prior to Stx challenge measured after 24 hrs by LDH assay | Chlorocebus sabaeus | 6 | ALA3124763 | cell-based format | Scientific Literature | |
5. | ALA3129873 | B | Inhibition of furin (unknown origin) assessed as HA5-mediated membrane fusion at 100 uM after 36 hrs by cell-based luciferase reporter gene assay | Homo sapiens | 6 | ALA3124763 | cell-based format | Scientific Literature | |
6. | ALA3129874 | B | Competitive inhibition of recombinant furin (unknown origin) using as substrate after 60 mins | Homo sapiens | 10 | ALA3124763 | single protein format | Scientific Literature | |
7. | ALA3129875 | T | Acute toxicity in iv dosed mouse | Mus musculus | 6 | ALA3124763 | organism-based format | Scientific Literature | |
8. | ALA3129876 | A | Cytotoxicity against MDCK cells up to 100 uM after 24 hrs by MTT assay | Canis lupus familiaris | 1 | ALA3124763 | cell-based format | Scientific Literature | |
9. | ALA3129877 | A | Cytotoxicity against human A549 cells up to 100 uM after 24 hrs by MTT assay | Homo sapiens | 1 | ALA3124763 | cell-based format | Scientific Literature | |
10. | ALA3129878 | A | Cytotoxicity against human HEK293FT cells at 100 uM after 4 hrs by LDH assay | Homo sapiens | 6 | ALA3124763 | cell-based format | Scientific Literature | |
11. | ALA3129879 | A | Cytotoxicity against human HEK293FT cells after 24 hrs by MTT assay | Homo sapiens | 6 | ALA3124763 | cell-based format | Scientific Literature | |
12. | ALA3129880 | P | Drug degradation in human DU145 cell culture medium assessed as deltaKKRT formation at 20 ug after 6 hrs by MALDI-TOF analysis | 2 | ALA3124763 | cell-based format | Scientific Literature | ||
13. | ALA3129881 | P | Drug degradation in human DU145 cell culture medium assessed as deltaKRT formation at 20 ug after 6 hrs by MALDI-TOF analysis | 1 | ALA3124763 | cell-based format | Scientific Literature | ||
14. | ALA3130016 | P | Drug degradation in human DU145 cell culture medium assessed as deltaRT formation at 20 ug after 6 hrs by MALDI-TOF analysis | 2 | ALA3124763 | cell-based format | Scientific Literature | ||
15. | ALA3130017 | P | Drug degradation in human DU145 cell culture medium assessed as Ac-RARRKKR formation at 20 ug after 6 hrs by MALDI-TOF analysis | 1 | ALA3124763 | cell-based format | Scientific Literature | ||
16. | ALA3130018 | A | Half life in CD1 mouse plasma at 35 ug by HPLC analysis | Mus musculus | 9 | ALA3124763 | cell-free format | Scientific Literature | |
17. | ALA3130019 | A | Half life in human DU145 cells by HPLC analysis | Homo sapiens | 1 | ALA3124763 | cell-based format | Scientific Literature | |
18. | ALA3130020 | A | Half life in human DU145 cells by HPLC analysis in presence of FBS | Homo sapiens | 1 | ALA3124763 | cell-based format | Scientific Literature | |
19. | ALA3130021 | P | Half life in cell culture medium by HPLC analysis in presence of FBS | 1 | ALA3124763 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA4689550 | B | Inhibition of recombinant soluble human furin using pyroGlu-Arg-Thr-Lys-Arg-methyl-coumaryl-7-amide as substrate measured after 1 hr | Homo sapiens | 97 | ALA4680371 | single protein format | Scientific Literature |