# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3767598 | ADME | Induction of phospholidosis in human HepG2 cells incubated overnight by LDH assay in presence of fluorescent labeled phospholipid probe NBD-PE | Homo sapiens | 12 | ALA3763146 | cell-based format | Scientific Literature | |
2. | ALA3767599 | Binding | Inhibition of human SERT expressed in HEK293 cells preincubated for 30 mins followed by fluorescent substrate addition measured after 30 mins by plate reader analysis | Homo sapiens | 13 | ALA3763146 | cell-based format | Scientific Literature | |
3. | ALA3767766 | Physicochemical | Distribution coefficient, logD of the compound at pH 7.4 | 9 | ALA3763146 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3767767 | Binding | Inhibition of human Nav1.2 channel expressed in Xenopus oocytes by two-intracellular microelectrode voltage clamp method | Homo sapiens | 12 | ALA3763146 | cell-based format | Scientific Literature | |
5. | ALA3767768 | Binding | Displacement of [3H]-diltiazem from human Cav1.2 channel | Homo sapiens | 13 | ALA3763146 | single protein format | Scientific Literature | |
6. | ALA3767769 | Binding | Binding affinity to human ERG channel | Homo sapiens | 13 | ALA3763146 | single protein format | Scientific Literature | |
7. | ALA3767770 | ADME | Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation | Homo sapiens | 8 | ALA3763146 | tissue-based format | Scientific Literature | |
8. | ALA3767771 | ADME | Inhibition of CYP2D6 in human liver microsomes assessed as dextraomethorphan O-demethylation | Homo sapiens | 8 | ALA3763146 | tissue-based format | Scientific Literature | |
9. | ALA3767772 | ADME | Inhibition of CYP2C9 in human liver microsomes assessed as diclofenac alpha'-hydroxylation | Homo sapiens | 8 | ALA3763146 | tissue-based format | Scientific Literature | |
10. | ALA3767773 | Binding | Displacement of [125]I-cyanopindolol from human recombinant beta2 adrenergic receptor after 1 hr by scintillation counting method | Homo sapiens | 13 | ALA3763146 | single protein format | Scientific Literature | |
11. | ALA3767774 | Binding | Displacement of [125]I-cyanopindolol from recombinant human beta1 adrenergic receptor after 1 hr by scintillation counting method | Homo sapiens | 13 | ALA3763146 | single protein format | Scientific Literature | |
12. | ALA3768477 | Functional | Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay relative to (R)-(-)-isoproterenol | Homo sapiens | 13 | ALA3763146 | cell-based format | Scientific Literature | |
13. | ALA3768478 | Functional | Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay | Homo sapiens | 13 | ALA3763146 | cell-based format | Scientific Literature | |
14. | ALA3768481 | ADME | Stability in human plasma assessed as parent compound remaining at 24 hrs by LC-MS analysis | Homo sapiens | 6 | ALA3763146 | cell-free format | Scientific Literature | |
15. | ALA3768501 | ADME | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 6 | ALA3763146 | tissue-based format | Scientific Literature | |
16. | ALA3768502 | ADME | Intrinsic clearance in dog liver microsomes | Canis lupus familiaris | 6 | ALA3763146 | tissue-based format | Scientific Literature | |
17. | ALA3768503 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 6 | ALA3763146 | tissue-based format | Scientific Literature | |
18. | ALA3768504 | ADME | Intrinsic clearance in rhesus monkey liver microsomes | Macaca mulatta | 6 | ALA3763146 | tissue-based format | Scientific Literature | |
19. | ALA3768505 | ADME | Stability in rat plasma assessed as parent compound remaining at 24 hrs by LC-MS analysis | Rattus norvegicus | 6 | ALA3763146 | cell-free format | Scientific Literature | |
20. | ALA3768715 | ADME | Stability in dog plasma assessed as parent compound remaining at 24 hrs by LC-MS analysis | Canis lupus familiaris | 5 | ALA3763146 | cell-free format | Scientific Literature |