| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3136075 | B | Destabilization of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase assessed as increase in enzyme sensitivity to trypsin proteolysis at 750 uM by SDS-PAGE mthod | Cryptosporidium hominis | 1 | single protein format | Scientific Literature | ||
| 2. | ALA3136077 | B | Inhibition of human DHFR | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA3136078 | B | Inhibition of thymidylate synthase activity of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase by steady state kinetic assay | Cryptosporidium hominis | 1 | single protein format | Scientific Literature | ||
| 4. | ALA3136079 | B | Inhibition of DHFR activity of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase beta face mutant by steady state kinetic assay relative wild type TS-DHFR | Cryptosporidium hominis | 1 | assay format | Scientific Literature | ||
| 5. | ALA3136080 | B | Inhibition of DHFR activity of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase beta face mutant by steady state kinetic assay | Cryptosporidium hominis | 1 | assay format | Scientific Literature | ||
| 6. | ALA3136081 | B | Noncompetitive inhibition of DHFR activity of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase by Lineweaver-Burk plot | Cryptosporidium hominis | 2 | single protein format | Scientific Literature | ||
| 7. | ALA3136082 | B | Noncompetitive inhibition of DHFR activity of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase assessed as effect on enzyme Km using NADPH substrate by steady state kinetic assay | Cryptosporidium hominis | 2 | single protein format | Scientific Literature | ||
| 8. | ALA3136083 | B | Noncompetitive inhibition of DHFR activity of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase assessed as reduction in enzyme Vmax using NADPH substrate by steady state kinetic assay | Cryptosporidium hominis | 2 | single protein format | Scientific Literature | ||
| 9. | ALA3136084 | B | Noncompetitive mixed type inhibition of DHFR activity of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase assessed as increase in enzyme Km using H2folate substrate by steady state kinetic assay | Cryptosporidium hominis | 2 | single protein format | Scientific Literature | ||
| 10. | ALA3136203 | B | Noncompetitive mixed type inhibition of DHFR activity of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase assessed as reduction in enzyme Vmax using H2folate substrate by steady state kinetic assay | Cryptosporidium hominis | 2 | single protein format | Scientific Literature | ||
| 11. | ALA3136204 | B | Inhibition of DHFR activity of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase by steady state kinetic assay | Cryptosporidium hominis | 2 | single protein format | Scientific Literature |
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