# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3215100 | F | PubChem BioAssay. Discovery and structure-activity relationship of a novel choline transporter inhibitor. (Class of assay: confirmatory) | 13 | assay format | PubChem BioAssays | |||
2. | ALA3215119 | F | PubChem BioAssay. Discovery and structure-activity relationship of a novel choline transporter inhibitor, Selectivity Studies. (Class of assay: confirmatory) | 72 | assay format | PubChem BioAssays | |||
3. | ALA3404111 | B | Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity at 5 uM in presence of 100 nM [3H]choline by [3H]choline uptake assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
4. | ALA3404112 | B | Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity at 5 uM in presence of 10 uM [3H]choline by [3H]choline uptake assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
5. | ALA3404113 | B | Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 100 nM [3H]choline by [3H]choline uptake assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
6. | ALA3404114 | B | Inhibition of human CHT Leu530Ala and Val531Ala mutant expressed in HEK293 cells assessed as remaining transporter activity in presence of 10 uM [3H]choline by [3H]choline uptake assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
7. | ALA3404116 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 6 | assay format | Scientific Literature | ||
8. | ALA3404117 | A | Fraction unbound in mouse plasma by equilibrium dialysis method | Mus musculus | 6 | cell-free format | Scientific Literature | ||
9. | ALA3404118 | A | Inhibition of human CYP1A2 | Homo sapiens | 6 | single protein format | Scientific Literature | ||
10. | ALA3404119 | A | Inhibition of human CYP2C9 | Homo sapiens | 6 | single protein format | Scientific Literature | ||
11. | ALA3404120 | A | Inhibition of human CYP2D6 | Homo sapiens | 6 | single protein format | Scientific Literature | ||
12. | ALA3404121 | A | Inhibition of human CYP3A4 | Homo sapiens | 6 | single protein format | Scientific Literature | ||
13. | ALA3404122 | A | Plasma concentration in mouse at 1 mg/kg, ip administered as cassette dosing | Mus musculus | 6 | organism-based format | Scientific Literature | ||
14. | ALA3404123 | A | Drug level in mouse brain at 1 mg/kg, ip administered as cassette dosing | Mus musculus | 6 | organism-based format | Scientific Literature | ||
15. | ALA3404124 | A | Ratio of drug level in brain to plasma in mouse at 1 mg/kg, ip administered as cassette dosing | Mus musculus | 6 | organism-based format | Scientific Literature | ||
16. | ALA3404125 | A | Hepatic clearance in mouse liver microsomes | Mus musculus | 6 | assay format | Scientific Literature |