# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1833052 | Toxicity | Toxicity in athymic nu/nu Harlan mouse xenografted with human HCT116 cells assessed as body weight loss at 100 mg/kg, po QD for 7 days measured on day 5 | Mus musculus | 1 | ALA1828590 | organism-based format | Scientific Literature | |
2. | ALA1831366 | Functional | Antitumor activity against human HCT116 cells xenografted in athymic nu/nu Harlan mouse assessed as tumor growth inhibition at 50 mg/kg, po qd for 7 days measured on day 22 | Homo sapiens | 1 | ALA1828590 | organism-based format | Scientific Literature | |
3. | ALA1831367 | Functional | Antitumor activity against human HCT116 cells xenografted in athymic nu/nu Harlan mouse assessed as tumor growth inhibition at 100 mg/kg, po qd for 7 days measured on day 22 | Homo sapiens | 1 | ALA1828590 | organism-based format | Scientific Literature | |
4. | ALA1831368 | Functional | Antitumor activity against human HCT116 cells xenografted in athymic nu/nu Harlan mouse assessed as tumor growth inhibition at 200 mg/kg, po qd for 7 days measured on day 22 | Homo sapiens | 1 | ALA1828590 | organism-based format | Scientific Literature | |
5. | ALA1831369 | Toxicity | Toxicity in athymic nu/nu Harlan mouse xenografted with human HCT116 cells assessed as body weight loss at 50 mg/kg, po QD for 7 days measured on day 5 | Mus musculus | 1 | ALA1828590 | organism-based format | Scientific Literature | |
6. | ALA1831370 | Toxicity | Toxicity in athymic nu/nu Harlan mouse xenografted with human HCT116 cells assessed as body weight loss at 200 mg/kg, po QD for 21 days measured on day 5 | Mus musculus | 1 | ALA1828590 | organism-based format | Scientific Literature | |
7. | ALA1831371 | Toxicity | Toxicity in athymic nu/nu Harlan mouse xenografted with human HCT116 cells assessed as mouse survival at 50 mg/kg, po QD for 7 days measured on day 22 | Mus musculus | 1 | ALA1828590 | organism-based format | Scientific Literature | |
8. | ALA1831372 | Toxicity | Toxicity in athymic nu/nu Harlan mouse xenografted with human HCT116 cells assessed as mouse survival at 100 mg/kg, po QD for 7 days measured on day 22 | Mus musculus | 1 | ALA1828590 | organism-based format | Scientific Literature | |
9. | ALA1832531 | ADME | Half life in human liver microsomes | Homo sapiens | 11 | ALA1828590 | microsome format | Scientific Literature | |
10. | ALA1832532 | ADME | Half life in mouse liver microsomes | Mus musculus | 11 | ALA1828590 | microsome format | Scientific Literature | |
11. | ALA1832808 | ADME | Half life in rat liver microsomes | Rattus norvegicus | 8 | ALA1828590 | microsome format | Scientific Literature | |
12. | ALA1832809 | ADME | Half life in dog liver microsomes | Canis lupus familiaris | 8 | ALA1828590 | microsome format | Scientific Literature | |
13. | ALA1832810 | Physicochemical | Kinetic solubility of the compound at pH 7 with 2.5% DMSO | 8 | ALA1828590 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA1832811 | Physicochemical | 1-Octanol-sodium phosphate buffer distribution coefficient, log D of the compound at pH 7.4 | 8 | ALA1828590 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA1832812 | ADME | Apparent permeability from apical to basolateral side of human Caco2 cells | Homo sapiens | 8 | ALA1828590 | cell-based format | Scientific Literature | |
16. | ALA1832813 | ADME | Apparent permeability from basolateral to apical side of human Caco2 cells | Homo sapiens | 7 | ALA1828590 | cell-based format | Scientific Literature |