# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3227039 | B | Displacement of [3H]-N-methyl scopolamine from human cloned muscarinic M3 receptor | Homo sapiens | 27 | ALA3217601 | single protein format | Scientific Literature | |
2. | ALA3227040 | F | Agonist activity at human beta-2 adrenoceptor expressed in CHO cells assessed as stimulation of intracellular cAMP production | Homo sapiens | 27 | ALA3217601 | cell-based format | Scientific Literature | |
3. | ALA3227041 | T | Genotoxicity in Salmonella typhimurium assessed by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | ALA3217601 | organism-based format | Scientific Literature | |
4. | ALA3227042 | B | Agonist activity at beta-1 adrenoceptor (unknown origin) | Homo sapiens | 27 | ALA3217601 | single protein format | Scientific Literature | |
5. | ALA3227043 | A | Drug metabolism of the compound in human liver microsomes assessed as glucuronidation in absence of NADPH and presence of microsomal activator Brij58 and UDPGA | Homo sapiens | 27 | ALA3217601 | assay format | Scientific Literature | |
6. | ALA3227044 | A | Intrinsic clearance in human liver microsomes assessed as glucuronidation in absence of NADPH and presence of microsomal activator Brij58 and UDPGA | Homo sapiens | 27 | ALA3217601 | assay format | Scientific Literature | |
7. | ALA3227045 | A | Drug metabolism in human hepatocytes assessed as formation of phenol glucuronide and sulfate metabolite by LC/MS/MS analysis | Homo sapiens | 1 | ALA3217601 | cell-based format | Scientific Literature | |
8. | ALA3227046 | B | Ratio of EC50 for human beta-2 adrenoceptor measured after drug washout to EC50 for human beta-2 adrenoceptor | Homo sapiens | 1 | ALA3217601 | single protein format | Scientific Literature | |
9. | ALA3227047 | B | Displacement of [3H]-N-methyl scopolamine from human cloned muscarinic M3 receptor assessed as time taken to reach 50% of total [3H]-NMS | Homo sapiens | 1 | ALA3217601 | single protein format | Scientific Literature | |
10. | ALA3227048 | B | Modulation of beta-2 adrenoceptor/muscarinic M3 receptor in guinea pig trachea assessed as inhibition of electric field stimulated muscle contraction by measuring release of endogenous acetylcholine | Cavia porcellus | 1 | ALA3217601 | tissue-based format | Scientific Literature | |
11. | ALA3227049 | B | Modulation of beta-2 adrenoceptor/muscarinic M3 receptor in guinea pig trachea assessed as time taken for muscle tone at submaximal concentration of compound to recover by 50% of inhibition induced | Cavia porcellus | 1 | ALA3217601 | tissue-based format | Scientific Literature | |
12. | ALA3227050 | B | Antagonist activity at muscarinic M3 receptor in guinea pig trachea assessed as inhibition of electric field stimulated muscle contraction by measuring release of endogenous acetylcholine in presence of propranolol | Cavia porcellus | 1 | ALA3217601 | single protein format | Scientific Literature | |
13. | ALA3227051 | B | Antagonist activity at muscarinic M3 receptor in guinea pig trachea assessed as time taken for muscle tone at submaximal concentration of compound to recover by 50% of inhibition induced in presence of propranolol | Cavia porcellus | 1 | ALA3217601 | single protein format | Scientific Literature | |
14. | ALA3227052 | B | Agonist activity at beta-2 adrenoceptor in guinea pig trachea assessed as inhibition of histamine-induced muscle contraction | Cavia porcellus | 1 | ALA3217601 | single protein format | Scientific Literature | |
15. | ALA3227369 | F | Bronchodilatory activity in intratracheally dosed dog assessed as inhibition of methacholine-induced bronchoconstriction | Canis lupus familiaris | 1 | ALA3217601 | organism-based format | Scientific Literature | |
16. | ALA3227370 | F | Bronchodilatory activity in intratracheally dosed dog assessed as duration of inhibition of methacholine-induced bronchoconstriction | Canis lupus familiaris | 1 | ALA3217601 | organism-based format | Scientific Literature | |
17. | ALA3227371 | F | Bronchodilatory activity in intratracheally dosed dog assessed as inhibition of methacholine-induced bronchoconstriction in presence of propranolol | Canis lupus familiaris | 1 | ALA3217601 | organism-based format | Scientific Literature | |
18. | ALA3227373 | F | Bronchodilatory activity in guinea pig in presence of propranolol | Cavia porcellus | 1 | ALA3217601 | organism-based format | Scientific Literature | |
19. | ALA3227374 | F | Bronchodilatory activity in intratracheally dosed dog assessed as inhibition of methacholine-induced bronchoconstriction in presence of NK2 agonist BANA | Canis lupus familiaris | 1 | ALA3217601 | organism-based format | Scientific Literature | |
20. | ALA3227375 | F | Bronchodilatory activity in guinea pig in presence of NK2 agonist BANA | Cavia porcellus | 1 | ALA3217601 | organism-based format | Scientific Literature |